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Literature summary for 1.4.3.4 extracted from

  • Herraiz, T.; Flores, A.; Fernandez, L.
    Analysis of monoamine oxidase (MAO) enzymatic activity by high-performance liquid chromatography-diode array detection combined with an assay of oxidation with a peroxidase and its application to MAO inhibitors from foods and plants (2018), J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 1073, 136-144 .
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
Clorgyline
-
 Homo sapiens
kaempferol
-
 Homo sapiens
methylene blue
-
 Homo sapiens
additional information no inhibition by catechin and cyanidin; no inhibitipon by catechin and cyanidin Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion outer membrane Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens P21397
-
-
Homo sapiens P27338
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
kynuramine + H2O + O2 a method is decribed to measure MAO activity and inhibition based on the oxidation of kynuramine determined by HPLC-DAD, combined in the same assay with the oxidation of a peroxidase substrate Homo sapiens 4-hydroxyquinoline + NH3 + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
MAO-A
-
 Homo sapiens
MAO-B
-
 Homo sapiens

General Information

General Information Comment Organism
drug target inhibitors of MAO-A and MAO-B isozymes are useful as antidepressants and neuroprotectants Homo sapiens
metabolism monoamine oxidase (MAO) enzymes catalyze the oxidative deamination of biogenic amines and neurotransmitters and produce ammonia, aldehydes, and hydrogen peroxide which is involved in oxidative processes Homo sapiens