Application | Comment | Organism |
---|---|---|
medicine | the MAO B inhibitor selegiline is efficacious in the therapeutic management of Parkinson's disease | Homo sapiens |
medicine | the MAO inhibitor moclobemide is promising in the therapeutic management of post-traumatic stress disorder and panic disorder | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
moclobemide | the MAO inhibitor is promising in the therapeutic management of post-traumatic stress disorder and panic disorder; the MAO inhibitor is promising in the therapeutic management of post-traumatic stress disorder and panic disorder | Homo sapiens | |
selegiline | the MAO B inhibitor is efficacious in the therapeutic management of Parkinson's disease | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
mitochondrion | - |
Mus musculus | 5739 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Mus musculus | MAO A KO mice display attenuated endocrine responses to major stressors, such as restraint, cold temperature, prolonged water deprivation and chronic variable stress | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P21397 | - |
- |
Homo sapiens | P27338 | - |
- |
Mus musculus | Q64133 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood platelet | MAO B is the only isoform in platelets and lymphocytes | Homo sapiens | - |
fibroblast | MAO A is prevalent in fibroblasts and placental tissue | Homo sapiens | - |
lymphocyte | MAO B is the only isoform in platelets and lymphocytes | Homo sapiens | - |
placenta | MAO A is prevalent in fibroblasts and placental tissue | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | MAO A KO mice display attenuated endocrine responses to major stressors, such as restraint, cold temperature, prolonged water deprivation and chronic variable stress | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
MAO A | - |
Homo sapiens |
MAO A | - |
Mus musculus |
MAO B | - |
Homo sapiens |
monoamine oxidase | - |
Homo sapiens |
monoamine oxidase | - |
Mus musculus |