Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Semicarbazide | - |
Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Rattus norvegicus | - |
- |
membrane | - |
Rattus norvegicus | 16020 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | required | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelium | - |
Rattus norvegicus | - |
liver | luminal expression, immunohistochemic analysis, overview | Rattus norvegicus | - |
serum | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
benzylamine + H2O + O2 | - |
Rattus norvegicus | benzaldehyde + NH3 + H2O2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | - |
Rattus norvegicus |
Synonyms | Comment | Organism |
---|---|---|
semicarbazide-sensitive amine oxidase | - |
Rattus norvegicus |
SSAO | - |
Rattus norvegicus |
VAP-1 | - |
Rattus norvegicus |
vascular adhesion protein 1 | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
physiological function | VAP-1 mediates lymphocyte adhesion to endothelia at sites of inflammation in vitro and in vivo. Inhibition of the SSAO activity of the enzyme by semicarbazid significantly decreases inflammatory cell infiltration in liver allografts, but does not influence the luminal expression of VAP-1 in the liver allografts | Rattus norvegicus |