Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Bothrops marajoensis | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
72000 | - |
x * 72000, SDS-PAGE | Bothrops marajoensis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-leucine + H2O + O2 | Bothrops marajoensis | - |
2-oxo-4-methylvaleric acid + NH3 + H2O2 | - |
? | |
additional information | Bothrops marajoensis | the L-amino acid oxidase from Bothrops marajoensis is able to inhibit the growth of several microorganisms, including Staphylococcus aureus, Candida albicans, Pseudomonas aeruginosa,and Leishmania sp.. The enzyme inhibits the growth of promastigote forms of Leishmania amazonensis and Leishmania chagasi with IC50 values of 2.55 mg/mL and 2.86 mg/mL, respectively | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bothrops marajoensis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native enzyme to high molecular homogeneity by ion exchange chromatography and reverse phase chromatography, followed by anion exchange chromatgography, ultrafiltration, and gel filtration | Bothrops marajoensis |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | - |
Bothrops marajoensis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-leucine + H2O + O2 | - |
Bothrops marajoensis | 2-oxo-4-methylvaleric acid + NH3 + H2O2 | - |
? | |
additional information | the L-amino acid oxidase from Bothrops marajoensis is able to inhibit the growth of several microorganisms, including Staphylococcus aureus, Candida albicans, Pseudomonas aeruginosa,and Leishmania sp.. The enzyme inhibits the growth of promastigote forms of Leishmania amazonensis and Leishmania chagasi with IC50 values of 2.55 mg/mL and 2.86 mg/mL, respectively | Bothrops marajoensis | ? | - |
? | |
additional information | LAAO catalyzes the stereospecific oxidative deamination of an L-amino acid substrate, releasing the corresponding 2-oxo acid and resulting in the production of hydrogen peroxide and ammonia | Bothrops marajoensis | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 72000, SDS-PAGE | Bothrops marajoensis |
Synonyms | Comment | Organism |
---|---|---|
L-amino acid: O2 oxidoreductase | - |
Bothrops marajoensis |
LAAO | - |
Bothrops marajoensis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Bothrops marajoensis |