Application | Comment | Organism |
---|---|---|
medicine | LAO potently induces lesions in lungs and livers. LAO causes severe pneumorrhagia, pulmonary interstitial edema, fusion of pulmonary alveoli, cardiac interstitial edema and bleeding when being intravenously injected into BALB/c mice. Also induces liver cell necrosis and release of cytokines including IL-6, IL-12 and IL-2 from highly purified human peripheral blood monocytes and T cells, respectively. The ability of LAO will contribute to the understanding of the pathogenesis of snakebite wound | Gloydius ussuriensis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.11 | - |
L-leucine | - |
Gloydius ussuriensis | |
0.27 | - |
L-valine | - |
Gloydius ussuriensis | |
0.36 | - |
L-asparagine | - |
Gloydius ussuriensis | |
0.88 | - |
L-methionine | - |
Gloydius ussuriensis | |
0.97 | - |
L-lysine | - |
Gloydius ussuriensis | |
1.57 | - |
L-tyrosine | - |
Gloydius ussuriensis | |
2.3 | - |
L-tryptophan | - |
Gloydius ussuriensis | |
2.33 | - |
L-arginine | - |
Gloydius ussuriensis | |
4.02 | - |
L-isoleucine | - |
Gloydius ussuriensis | |
4.28 | - |
L-phenylalanine | - |
Gloydius ussuriensis | |
4.97 | - |
L-histidine | - |
Gloydius ussuriensis | |
5.12 | - |
L-alanine | - |
Gloydius ussuriensis |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
58000 | - |
2 * 60000, SDS-PAGE under reducing conditions, 2 * 58000, SDS-PAGE under nonreducing conditions | Gloydius ussuriensis |
60000 | - |
2 * 60000, SDS-PAGE under reducing conditions, 2 * 58000, SDS-PAGE under nonreducing conditions | Gloydius ussuriensis |
108800 | - |
gel filtration | Gloydius ussuriensis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Gloydius ussuriensis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
by gel filtration followed by ion-exchange chromatography, 51.3fold | Gloydius ussuriensis |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
venom | - |
Gloydius ussuriensis | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1.56 | - |
crude venom | Gloydius ussuriensis |
79.92 | - |
51.3fold purified | Gloydius ussuriensis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-alanine + H2O + O2 | - |
Gloydius ussuriensis | 2-oxopropanoic acid + NH3 + H2O2 | - |
? | |
L-arginine + H2O + O2 | - |
Gloydius ussuriensis | 2-oxo-5-guanidinovaleric acid + NH3 + H2O2 | - |
? | |
L-asparagine + H2O + O2 | - |
Gloydius ussuriensis | alpha-ketosuccinamic acid + NH3 + H2O2 | - |
? | |
L-histidine + H2O + O2 | - |
Gloydius ussuriensis | 3-(1H-imidazol-4-yl)-2-oxopropionic acid + NH3 + H2O2 | - |
? | |
L-isoleucine + H2O + O2 | - |
Gloydius ussuriensis | 3-methyl-2-oxopentanoic acid + NH3 + H2O2 | - |
? | |
L-leucine + H2O + O2 | - |
Gloydius ussuriensis | 4-methyl-2-oxopentanoic acid + NH3 + H2O2 | - |
? | |
L-lysine + H2O + O2 | - |
Gloydius ussuriensis | 6-amino-2-oxohexanoic acid + NH3 + H2O2 | - |
? | |
L-methionine + H2O + O2 | - |
Gloydius ussuriensis | 4-methylsulfanyl-2-oxobutanoate + NH3 + H2O2 | - |
? | |
L-phenylalanine + H2O + O2 | - |
Gloydius ussuriensis | phenylpyruvate + NH3 + H2O2 | - |
? | |
L-tryptophan + H2O + O2 | - |
Gloydius ussuriensis | 3-indole-2-oxopropanoate + NH3 + H2O2 | - |
? | |
L-tyrosine + H2O + O2 | - |
Gloydius ussuriensis | p-hydroxyphenylpyruvate + NH3 + H2O2 | - |
? | |
L-valine + H2O + O2 | - |
Gloydius ussuriensis | 2-oxoisovalerate + NH3 + H2O2 | - |
? | |
additional information | does not hydrolyze casein and synthetic substrates including N-benzoyl-L-arginine ethylester or N-benzoyl-L-arginine p-nitroanilide | Gloydius ussuriensis | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 60000, SDS-PAGE under reducing conditions, 2 * 58000, SDS-PAGE under nonreducing conditions | Gloydius ussuriensis |
Synonyms | Comment | Organism |
---|---|---|
LAO | - |
Gloydius ussuriensis |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
4.15 | - |
L-histidine | - |
Gloydius ussuriensis | |
5.08 | - |
L-valine | - |
Gloydius ussuriensis | |
5.26 | - |
L-asparagine | - |
Gloydius ussuriensis | |
6.33 | - |
L-isoleucine | - |
Gloydius ussuriensis | |
6.58 | - |
L-tryptophan | - |
Gloydius ussuriensis | |
8.42 | - |
L-tyrosine | - |
Gloydius ussuriensis | |
10.51 | - |
L-lysine | - |
Gloydius ussuriensis | |
22.54 | - |
L-arginine | - |
Gloydius ussuriensis | |
24.13 | - |
L-methionine | - |
Gloydius ussuriensis | |
26.89 | - |
L-alanine | - |
Gloydius ussuriensis | |
48.22 | - |
L-leucine | - |
Gloydius ussuriensis | |
48.23 | - |
L-phenylalanine | - |
Gloydius ussuriensis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
5.2 | - |
- |
Gloydius ussuriensis |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
4.4 | 9.6 | - |
Gloydius ussuriensis |