Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(2-((3,4-dimethylphenyl)amino)-4-methylthiazol-5-yl)-ethanone | - |
Homo sapiens | |
1-(2-((3-chloro-4-methylphenyl)amino)-4-methylthiazol-5-yl)ethanone | - |
Homo sapiens | |
1-(2-((3-fluoro-4-methylphenyl)amino)-4-methylthiazol-5-yl)ethanone | - |
Homo sapiens | |
1-(2-((4-(tert-butyl)phenyl)amino)-4-methylthiazol-5-yl)-ethanone | - |
Homo sapiens | |
1-(2-((4-bromo-3-(trifluoromethyl)phenyl)amino)-4-methylthiazol-5-yl)ethanone | - |
Homo sapiens | |
1-(2-((4-bromophenyl)amino)-4-methylthiazol-5-yl)-ethanone | - |
Homo sapiens | |
1-(2-((4-chloro-3-(trifluoromethyl)phenyl)amino)-4-methylthiazol-5-yl)ethanone | - |
Homo sapiens | |
1-(2-(anthracen-2-ylamino)-4-methylthiazol-5-yl)ethan-1-one | - |
Homo sapiens | |
1-(4-methyl-2-(naphthalen-2-ylamino)thiazol-5-yl)ethan-1-one | - |
Homo sapiens | |
1-(4-methyl-2-(phenylamino)thiazol-5-yl)ethanone | - |
Homo sapiens | |
brequinar | - |
Homo sapiens | |
ethyl 2-((2,3-dihydro-1h-inden-5-yl)amino)-4-phenylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-((3'-methoxy-[1,1'-biphenyl]-4-yl)amino)-4-phenylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-((3,4-dichlorophenyl)amino)-4-phenylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-((3,4-dimethylphenyl)amino)-4-methylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-((3,4-dimethylphenyl)amino)-4-phenylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-((3,5-dichlorophenyl)amino)-4-phenylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-((3,5-difluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)-amino)-4-phenylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-((3-chloro-4-((2-chloro-6-fluorobenzyl)oxy)phenyl)-amino)-4-phenylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-((3-chloro-4-methylphenyl)amino)-4-cyclopropylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-((3-chloro-4-methylphenyl)amino)-4-methylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-((3-chloro-4-methylphenyl)amino)-4-phenylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-((3-chloro-4-phenoxyphenyl)amino)-4-phenylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-((3-fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)amino)-4-phenylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-((3-fluoro-4-methylphenyl)amino)-4-methylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-((3-fluoro-4-methylphenyl)amino)-4-phenylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-((3-fluoro-[1,1'-biphenyl]-4-yl)amino)-4-phenylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-((4-(benzyloxy)-3-chlorophenyl)amino)-4-phenylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-((4-(tert-butyl)phenyl)amino)-4-phenylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-((4-bromo-2-methylphenyl)amino)-4-phenylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-((4-bromo-3-(trifluoromethyl)phenyl)amino)-4-phenylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-((4-bromophenyl)amino)-4-methylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-((4-chloro-3-(trifluoromethyl)phenyl)amino)-4-(cyclopropanecarboxamido)thiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-((4-chloro-3-(trifluoromethyl)phenyl)amino)-4-phenylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-((4-chlorophenyl)amino)-4-phenylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-((4-methoxyphenyl)amino)-4-phenylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-(anthracen-2-ylamino)-4-phenylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-(benzo[d][1,3]dioxol-5-ylamino)-4-phenylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-(naphthalen-2-ylamino)-4-phenylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 2-([1,1'-biphenyl]-4-ylamino)-4-phenylthiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 4-(cyclopropanecarboxamido)-2-((3,4-dimethylphenyl)amino)thiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 4-(tert-butyl)-2-((3,4-dimethylphenyl)amino)thiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 4-(tert-butyl)-2-((3-chloro-4-methylphenyl)amino)-thiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 4-(tert-butyl)-2-((3-fluoro-4-methylphenyl)amino)-thiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 4-amino-2-((3,4-dimethylphenyl)amino)thiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 4-amino-2-((4-chloro-3-(trifluoromethyl)phenyl)-amino)thiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 4-benzamido-2-((3,4-dimethylphenyl)amino)thiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 4-benzamido-2-((4-chloro-3-(trifluoromethyl)phenyl)-amino)thiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 4-cyclopropyl-2-((3,4-dimethylphenyl)amino)thiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 4-cyclopropyl-2-((4-fluoro-3-methylphenyl)amino)-thiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 4-methyl-2-(naphthalen-2-ylamino)thiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 4-phenyl-2-((4-(trifluoromethyl)phenyl)amino)-thiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 4-phenyl-2-((5,6,7,8-tetrahydronaphthalen-2-yl)-amino)thiazole-5-carboxylate | - |
Homo sapiens | |
ethyl 4-phenyl-2-(phenylamino)thiazole-5-carboxylate | - |
Homo sapiens | |
leflunomide | - |
Homo sapiens | |
teriflunomide | - |
Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q02172 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-dihydroorotate + 2,6-dichlorophenolindophenol | - |
Homo sapiens | orotate + reduced 2,6-dichlorophenolindophenol | - |
? | |
(S)-dihydroorotate + decylubiquinone | - |
Homo sapiens | orotate + reduced decylubiquinone | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DHODH | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FMN | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000018 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 4-phenyl-2-((5,6,7,8-tetrahydronaphthalen-2-yl)-amino)thiazole-5-carboxylate | |
0.000026 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-((2,3-dihydro-1h-inden-5-yl)amino)-4-phenylthiazole-5-carboxylate | |
0.000029 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-(naphthalen-2-ylamino)-4-phenylthiazole-5-carboxylate | |
0.000035 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-((3-chloro-4-methylphenyl)amino)-4-phenylthiazole-5-carboxylate | |
0.000049 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-((3-fluoro-4-methylphenyl)amino)-4-phenylthiazole-5-carboxylate | |
0.000058 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-((3,4-dimethylphenyl)amino)-4-phenylthiazole-5-carboxylate | |
0.000128 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-((4-bromo-3-(trifluoromethyl)phenyl)amino)-4-phenylthiazole-5-carboxylate | |
0.000131 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-((4-chloro-3-(trifluoromethyl)phenyl)amino)-4-phenylthiazole-5-carboxylate | |
0.000163 | - |
at pH 8.0 and 22°C | Homo sapiens | teriflunomide | |
0.000174 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-((3,4-dichlorophenyl)amino)-4-phenylthiazole-5-carboxylate | |
0.000239 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-((4-chlorophenyl)amino)-4-phenylthiazole-5-carboxylate | |
0.000284 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-((4-(tert-butyl)phenyl)amino)-4-phenylthiazole-5-carboxylate | |
0.000311 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-((3,5-difluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)-amino)-4-phenylthiazole-5-carboxylate | |
0.000325 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 4-cyclopropyl-2-((3,4-dimethylphenyl)amino)thiazole-5-carboxylate | |
0.000372 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-((3-chloro-4-methylphenyl)amino)-4-cyclopropylthiazole-5-carboxylate | |
0.000393 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-((3,5-dichlorophenyl)amino)-4-phenylthiazole-5-carboxylate | |
0.000408 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 4-phenyl-2-((4-(trifluoromethyl)phenyl)amino)-thiazole-5-carboxylate | |
0.000453 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-(anthracen-2-ylamino)-4-phenylthiazole-5-carboxylate | |
0.000515 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 4-(tert-butyl)-2-((3,4-dimethylphenyl)amino)thiazole-5-carboxylate | |
0.000552 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 4-(tert-butyl)-2-((3-chloro-4-methylphenyl)amino)-thiazole-5-carboxylate | |
0.000562 | - |
at pH 8.0 and 22°C | Homo sapiens | 1-(4-methyl-2-(naphthalen-2-ylamino)thiazol-5-yl)ethan-1-one | |
0.000645 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 4-cyclopropyl-2-((4-fluoro-3-methylphenyl)amino)-thiazole-5-carboxylate | |
0.000652 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 4-(tert-butyl)-2-((3-fluoro-4-methylphenyl)amino)-thiazole-5-carboxylate | |
0.000784 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 4-phenyl-2-(phenylamino)thiazole-5-carboxylate | |
0.000887 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 4-methyl-2-(naphthalen-2-ylamino)thiazole-5-carboxylate | |
0.000969 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-((3-chloro-4-methylphenyl)amino)-4-methylthiazole-5-carboxylate | |
0.001108 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-(benzo[d][1,3]dioxol-5-ylamino)-4-phenylthiazole-5-carboxylate | |
0.001358 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-((3,4-dimethylphenyl)amino)-4-methylthiazole-5-carboxylate | |
0.00144 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-((4-methoxyphenyl)amino)-4-phenylthiazole-5-carboxylate | |
0.00193 | - |
at pH 8.0 and 22°C | Homo sapiens | 1-(2-((4-bromo-3-(trifluoromethyl)phenyl)amino)-4-methylthiazol-5-yl)ethanone | |
0.001987 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-((3-fluoro-4-methylphenyl)amino)-4-methylthiazole-5-carboxylate | |
0.00211 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 4-amino-2-((3,4-dimethylphenyl)amino)thiazole-5-carboxylate | |
0.00235 | - |
at pH 8.0 and 22°C | Homo sapiens | 1-(2-((4-chloro-3-(trifluoromethyl)phenyl)amino)-4-methylthiazol-5-yl)ethanone | |
0.00365 | - |
at pH 8.0 and 22°C | Homo sapiens | 1-(2-((4-(tert-butyl)phenyl)amino)-4-methylthiazol-5-yl)-ethanone | |
0.00385 | - |
at pH 8.0 and 22°C | Homo sapiens | 1-(2-((3,4-dimethylphenyl)amino)-4-methylthiazol-5-yl)-ethanone | |
0.00394 | - |
at pH 8.0 and 22°C | Homo sapiens | 1-(2-((3-chloro-4-methylphenyl)amino)-4-methylthiazol-5-yl)ethanone | |
0.00604 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-((4-chloro-3-(trifluoromethyl)phenyl)amino)-4-(cyclopropanecarboxamido)thiazole-5-carboxylate | |
0.00903 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 4-benzamido-2-((3,4-dimethylphenyl)amino)thiazole-5-carboxylate | |
0.00907 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-((4-bromophenyl)amino)-4-methylthiazole-5-carboxylate | |
0.01 | - |
at pH 8.0 and 22°C | Homo sapiens | 1-(4-methyl-2-(phenylamino)thiazol-5-yl)ethanone | |
0.01 | - |
at pH 8.0 and 22°C | Homo sapiens | 1-(2-((4-bromophenyl)amino)-4-methylthiazol-5-yl)-ethanone | |
0.01 | - |
at pH 8.0 and 22°C | Homo sapiens | 1-(2-((3-fluoro-4-methylphenyl)amino)-4-methylthiazol-5-yl)ethanone | |
0.01 | - |
at pH 8.0 and 22°C | Homo sapiens | 1-(2-(anthracen-2-ylamino)-4-methylthiazol-5-yl)ethan-1-one | |
0.01 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 4-amino-2-((4-chloro-3-(trifluoromethyl)phenyl)-amino)thiazole-5-carboxylate | |
0.01 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 4-(cyclopropanecarboxamido)-2-((3,4-dimethylphenyl)amino)thiazole-5-carboxylate | |
0.01 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 4-benzamido-2-((4-chloro-3-(trifluoromethyl)phenyl)-amino)thiazole-5-carboxylate | |
0.01 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-((4-bromo-2-methylphenyl)amino)-4-phenylthiazole-5-carboxylate | |
0.01 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-([1,1'-biphenyl]-4-ylamino)-4-phenylthiazole-5-carboxylate | |
0.01 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-((3'-methoxy-[1,1'-biphenyl]-4-yl)amino)-4-phenylthiazole-5-carboxylate | |
0.01 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-((3-fluoro-[1,1'-biphenyl]-4-yl)amino)-4-phenylthiazole-5-carboxylate | |
0.01 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-((3-fluoro-3'-methoxy-[1,1'-biphenyl]-4-yl)amino)-4-phenylthiazole-5-carboxylate | |
0.01 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-((3-chloro-4-phenoxyphenyl)amino)-4-phenylthiazole-5-carboxylate | |
0.01 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-((4-(benzyloxy)-3-chlorophenyl)amino)-4-phenylthiazole-5-carboxylate | |
0.01 | - |
at pH 8.0 and 22°C | Homo sapiens | ethyl 2-((3-chloro-4-((2-chloro-6-fluorobenzyl)oxy)phenyl)-amino)-4-phenylthiazole-5-carboxylate |