Crystallization (Comment) | Organism |
---|---|
in complex with inhibitors 2-[(2,5-dichlorophenyl)sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol and 2-[(2,5-dichlorophenyl)sulfanyl]-5-ethyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol. bindung induces a structural change in the N-terminal helix. Comparison with binding to Plasmodium falciparum enzyme | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-[(2,5-dichlorophenyl)sulfanyl]-5-ethyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol | compound has therapeutically relevant activity against human enzyme | Homo sapiens | |
2-[(2,5-dichlorophenyl)sulfanyl]-5-ethyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol | no specific inhibition of Plasmodium enzyme, good inhibitor of human enzyme | Plasmodium falciparum | |
2-[(2,5-dichlorophenyl)sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol | compound has therapeutically relevant activity against human enzyme | Homo sapiens | |
2-[(2,5-dichlorophenyl)sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol | no specific inhibition of Plasmodium enzyme, good inhibitor of human enzyme | Plasmodium falciparum | |
2-[(3,4-dichlorophenyl)sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol | compound is less active with human enzyme but good inhibitor of Plasmodium falciparum enzyme | Homo sapiens | |
2-[(3,4-dichlorophenyl)sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol | - |
Plasmodium falciparum | |
2-[(4-chlorophenyl)sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol | compound is less active with human enzyme but good inhibitor of Plasmodium falciparum enzyme | Homo sapiens | |
2-[(4-chlorophenyl)sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol | - |
Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q02127 | - |
- |
Plasmodium falciparum | - |
- |
- |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000013 | - |
or above, pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-[(2,5-dichlorophenyl)sulfanyl]-5-ethyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol | |
0.000051 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-[(2,5-dichlorophenyl)sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol | |
0.001 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | 2-[(4-chlorophenyl)sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol | |
0.0019 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | 2-[(3,4-dichlorophenyl)sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol | |
0.0065 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-[(3,4-dichlorophenyl)sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol | |
0.011 | - |
pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | 2-[(2,5-dichlorophenyl)sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol | |
0.039 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | 2-[(4-chlorophenyl)sulfanyl]-5-methyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol | |
0.1 | - |
or above, pH not specified in the publication, temperature not specified in the publication | Plasmodium falciparum | 2-[(2,5-dichlorophenyl)sulfanyl]-5-ethyl[1,2,4]triazolo[1,5-a]pyrimidin-7-ol |