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Literature summary for 1.3.3.3 extracted from
- Purification and properties of mouse liver coproporphyrinogen oxidase (1989), Eur. J. Biochem., 181, 417-421.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| lecithin | lowers Km, increases Vmax | Mus musculus |  |
| Non-ionic detergents | - |
Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5,5-dithiobis(2-nitrobenzoic acid) | significant inhibition, IC50: 0.05 mM | Mus musculus | |
| sodium cholate | - |
Mus musculus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.1 | - |
Coproporphyrinogen-III | presence of activating lecithin | Mus musculus | |
| 0.32 | - |
Coproporphyrinogen-III | - |
Mus musculus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 35000 | - |
2 * 35000, SDS-PAGE | Mus musculus |
| 70000 | - |
gel filtration | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| coproporphyrinogen-III + O2 + 2 H+ | Mus musculus | 6th enzyme in heme biosynthetic pathway | protoporphyrinogen-IX + 2 CO2 + 2 H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| to homogeneity, chromatography steps | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.06 | - |
- |
Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| coproporphyrinogen-III + O2 + 2 H+ | sixths enzyme in heme biosynthetic pathway | Mus musculus | protoporphyrinogen-IX + 2 CO2 + 2 H2O | - |
? | |
| coproporphyrinogen-III + O2 + 2 H+ | 6th enzyme in heme biosynthetic pathway | Mus musculus | protoporphyrinogen-IX + 2 CO2 + 2 H2O | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 35000, SDS-PAGE | Mus musculus |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.05 | - |
significant inhibition, IC50: 0.05 mM | Mus musculus | 5,5-dithiobis(2-nitrobenzoic acid) | |
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