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Literature summary for 1.3.1.9 extracted from
- In silico repositioning of cannabigerol as a novel inhibitor of the enoyl acyl carrier protein (ACP) reductase (InhA) (2019), Molecules, 24, 2567 .
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 5-pentyl-2-phenoxyphenol | - |
Mycobacterium tuberculosis |  |
| cannabichromene | 31% inhibition at 0.05 mM | Mycobacterium tuberculosis | |
| cis-cannabigerol | 78% inhibition at 0.05 mM | Mycobacterium tuberculosis | |
| triclosan | 56% inhibition at 0.0003 mM | Mycobacterium tuberculosis | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mycobacterium tuberculosis | P9WGR1 | - |
- |
| Mycobacterium tuberculosis H37Rv | P9WGR1 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ACP reductase | - |
Mycobacterium tuberculosis |
| enoyl acyl carrier protein reductase | - |
Mycobacterium tuberculosis |
| InhA | - |
Mycobacterium tuberculosis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Mycobacterium tuberculosis | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0052 | - |
at pH 6.8 and 25°C | Mycobacterium tuberculosis | cis-cannabigerol |
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