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Literature summary for 1.3.1.9 extracted from

  • Yadav, S.; Mandal, H.; Saravanan, V.; Das, P.; Singh, S.
    In vitro and in silico analysis of L. donovani enoyl acyl carrier protein reductase - A possible drug target (2021), J. Biomol. Struct. Dyn., 39, 6056-6069 .
    View publication on PubMed
Search for more literature for 1.3.1.9

Inhibitors

Inhibitors Comment Organism Structure
triclosan
-
 Leishmania donovani

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+ Leishmania donovani NADH is the preferred cofactor an acyl-[acyl-carrier protein] + NAD+
-
 ?
a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+ Leishmania donovani AG83 NADH is the preferred cofactor an acyl-[acyl-carrier protein] + NAD+
-
 ?
a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+ Leishmania donovani
-
 an acyl-[acyl-carrier protein] + NADP+
-
 ?
a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+ Leishmania donovani AG83
-
 an acyl-[acyl-carrier protein] + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Leishmania donovani E9BQL7
-
-
Leishmania donovani AG83 E9BQL7
-
-

Source Tissue

Source Tissue Comment Organism Textmining
amastigote
-
 Leishmania donovani
-
promastigote
-
 Leishmania donovani
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+ NADH is the preferred cofactor Leishmania donovani an acyl-[acyl-carrier protein] + NAD+
-
 ?
a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+ NADH is the preferred cofactor Leishmania donovani AG83 an acyl-[acyl-carrier protein] + NAD+
-
 ?
a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+
-
 Leishmania donovani an acyl-[acyl-carrier protein] + NADP+
-
 ?
a trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+
-
 Leishmania donovani AG83 an acyl-[acyl-carrier protein] + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
enoyl acyl carrier protein reductase
-
 Leishmania donovani
enoyl-ACP reductase
-
 Leishmania donovani
ENR
-
 Leishmania donovani

Cofactor

Cofactor Comment Organism Structure
NADH preferred cofactor Leishmania donovani
NADPH
-
 Leishmania donovani