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Literature summary for 1.3.1.9 extracted from

  • Pflegr, V.; Horvath, L.; Stolariova, J.; Pal, A.; Kordulakova, J.; Bosze, S.; Vinsova, J.; Kratky, M.
    Design and synthesis of 2-(2-isonicotinoylhydrazineylidene)propanamides as InhA inhibitors with high antitubercular activity (2021), Eur. J. Med. Chem., 223, 113668 .
    View publication on PubMed
Search for more literature for 1.3.1.9

Inhibitors

Inhibitors Comment Organism Structure
(E)-2-(2-ionicotinoylhydrazineylidene)-N-(3,4,5-trichlorophenyl)propanamide
-
 Mycobacterium avium
(E)-2-(2-ionicotinoylhydrazineylidene)-N-(3,4,5-trichlorophenyl)propanamide
-
 Mycobacterium kansasii
(E)-2-(2-ionicotinoylhydrazineylidene)-N-(3,4,5-trichlorophenyl)propanamide
-
 Mycobacterium tuberculosis
(E)-2-(2-isonicotinoylhydrazineylidene)-N-[3-(trifluoromethoxy)phenyl]propanamide
-
 Mycobacterium avium
(E)-2-(2-isonicotinoylhydrazineylidene)-N-[3-(trifluoromethoxy)phenyl]propanamide
-
 Mycobacterium kansasii
(E)-2-(2-isonicotinoylhydrazineylidene)-N-[3-(trifluoromethoxy)phenyl]propanamide
-
 Mycobacterium tuberculosis
(E)-2-(2-isonicotinoylhydrazineylidene)-N-[3-(trifluoromethyl)phenyl]propanamide
-
 Mycobacterium avium
(E)-2-(2-isonicotinoylhydrazineylidene)-N-[3-(trifluoromethyl)phenyl]propanamide
-
 Mycobacterium kansasii
(E)-2-(2-isonicotinoylhydrazineylidene)-N-[3-(trifluoromethyl)phenyl]propanamide
-
 Mycobacterium tuberculosis
(E)-2-(2-isonicotinoylhydrazineylidene)-N-[4-(perfluorooctyl)phenyl]propanamide
-
 Mycobacterium avium
(E)-2-(2-isonicotinoylhydrazineylidene)-N-[4-(perfluorooctyl)phenyl]propanamide
-
 Mycobacterium kansasii
(E)-2-(2-isonicotinoylhydrazineylidene)-N-[4-(perfluorooctyl)phenyl]propanamide
-
 Mycobacterium tuberculosis
(E)-2-(2-isonicotinoylhydrazineylidene)-N-[4-(trifluoromethoxy)phenyl]propanamide
-
 Mycobacterium avium
(E)-2-(2-isonicotinoylhydrazineylidene)-N-[4-(trifluoromethoxy)phenyl]propanamide
-
 Mycobacterium kansasii
(E)-2-(2-isonicotinoylhydrazineylidene)-N-[4-(trifluoromethoxy)phenyl]propanamide
-
 Mycobacterium tuberculosis
(E)-2-(2-isonicotinoylhydrazineylidene)-N-[4-(trifluoromethyl)phenyl]propanamide
-
 Mycobacterium avium
(E)-2-(2-isonicotinoylhydrazineylidene)-N-[4-(trifluoromethyl)phenyl]propanamide
-
 Mycobacterium kansasii
(E)-2-(2-isonicotinoylhydrazineylidene)-N-[4-(trifluoromethyl)phenyl]propanamide
-
 Mycobacterium tuberculosis
(E)-2-(2-isonicotinoylhydrazineylidene)-N-{4-[(trifluoromethyl)thio]phenyl}propanamide
-
 Mycobacterium avium
(E)-2-(2-isonicotinoylhydrazineylidene)-N-{4-[(trifluoromethyl)thio]phenyl}propanamide
-
 Mycobacterium kansasii
(E)-2-(2-isonicotinoylhydrazineylidene)-N-{4-[(trifluoromethyl)thio]phenyl}propanamide
-
 Mycobacterium tuberculosis
(E)-2-(2-isonicotinoylhydrazineylidene)propanoic acid
-
 Mycobacterium avium
(E)-2-(2-isonicotinoylhydrazineylidene)propanoic acid
-
 Mycobacterium kansasii
(E)-2-(2-isonicotinoylhydrazineylidene)propanoic acid
-
 Mycobacterium tuberculosis
(E)-N-(3,4-dichlorophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium avium
(E)-N-(3,4-dichlorophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium kansasii
(E)-N-(3,4-dichlorophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium tuberculosis
(E)-N-(3,4-difluorophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium avium
(E)-N-(3,4-difluorophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium kansasii
(E)-N-(3,4-difluorophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium tuberculosis
(E)-N-(3,5-dichlorophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium avium
(E)-N-(3,5-dichlorophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium kansasii
(E)-N-(3,5-dichlorophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium tuberculosis
(E)-N-(3-bromophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium avium
(E)-N-(3-bromophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium kansasii
(E)-N-(3-bromophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium tuberculosis
(E)-N-(3-chlorophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium avium
(E)-N-(3-chlorophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium kansasii
(E)-N-(3-chlorophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium tuberculosis
(E)-N-(3-fluorophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium avium
(E)-N-(3-fluorophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium kansasii
(E)-N-(3-fluorophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium tuberculosis
(E)-N-(3-iodophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium avium
(E)-N-(3-iodophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium kansasii
(E)-N-(3-iodophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium tuberculosis
(E)-N-(4-bromophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium avium
(E)-N-(4-bromophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium kansasii
(E)-N-(4-bromophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium tuberculosis
(E)-N-(4-chlorophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium avium
(E)-N-(4-chlorophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium kansasii
(E)-N-(4-chlorophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium tuberculosis
(E)-N-(4-fluorophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium avium
(E)-N-(4-fluorophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium kansasii
(E)-N-(4-fluorophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium tuberculosis
(E)-N-(4-iodophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium avium
(E)-N-(4-iodophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium kansasii
(E)-N-(4-iodophenyl)-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium tuberculosis
(E)-N-[3,5-bis(trifluoromethyl)phenyl]-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium avium
(E)-N-[3,5-bis(trifluoromethyl)phenyl]-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium kansasii
(E)-N-[3,5-bis(trifluoromethyl)phenyl]-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium tuberculosis
(E)-N-[4-(difluoromethoxy)phenyl]-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium avium
(E)-N-[4-(difluoromethoxy)phenyl]-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium kansasii
(E)-N-[4-(difluoromethoxy)phenyl]-2-(2-isonicotinoylhydrazineylidene)propanamide
-
 Mycobacterium tuberculosis
2-[2-[4-(1H-pyrrol-1-yl)benzoyl]hydrazineylidene]-N-(4-fluorophenyl)propanamide
-
 Mycobacterium kansasii
2-[2-[4-(1H-pyrrol-1-yl)benzoyl]hydrazineylidene]-N-(4-fluorophenyl)propanamide
-
 Mycobacterium tuberculosis
isoniazid
-
 Mycobacterium avium
isoniazid
-
 Mycobacterium kansasii
isoniazid
-
 Mycobacterium tuberculosis
additional information the enzyme is resistant to isoniazid, ansamycines, ofloxacin, and ethambutol Mycobacterium avium

Organism

Organism UniProt Comment Textmining
Mycobacterium avium
-
-
-
Mycobacterium avium 330/88
-
-
-
Mycobacterium kansasii
-
-
-
Mycobacterium kansasii 235/80
-
-
-
Mycobacterium tuberculosis
-
-
-
Mycobacterium tuberculosis H37Rv
-
-
-

Synonyms

Synonyms Comment Organism
InhA
-
 Mycobacterium avium
InhA
-
 Mycobacterium tuberculosis
InhA
-
 Mycobacterium kansasii

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Mycobacterium avium
NADH
-
 Mycobacterium tuberculosis
NADH
-
 Mycobacterium kansasii