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Literature summary for 1.3.1.78 extracted from

  • Byng, G.S.; Berry, A.; Jensen, R.A.
    Evolutionary implications of features of aromatic amino acid biosynthesis in the genus Acinetobacter (1985), Arch. Microbiol., 143, 122-129.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
L-tyrosine competitive inhibition Acinetobacter calcoaceticus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.005
-
NADP+ ATCC 23055 Acinetobacter calcoaceticus
0.313
-
L-arogenate ATCC 23055 Acinetobacter calcoaceticus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
210000
-
ATCC 23055, gel filtration Acinetobacter calcoaceticus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arogenate + NAD+ Acinetobacter calcoaceticus
-
L-tyrosine + NADH + CO2
-
?
L-arogenate + NAD+ Acinetobacter sp.
-
L-tyrosine + NADH + CO2
-
?
L-arogenate + NAD+ Acinetobacter lwoffii
-
L-tyrosine + NADH + CO2
-
?
L-arogenate + NAD+ Acinetobacter sp. C1W
-
L-tyrosine + NADH + CO2
-
?

Organism

Organism UniProt Comment Textmining
Acinetobacter calcoaceticus
-
ATCC 23055 and ATCC 14987
-
Acinetobacter lwoffii
-
ATCC 15309
-
Acinetobacter sp.
-
-
-
Acinetobacter sp. C1W
-
-
-

Purification (Commentary)

Purification (Comment) Organism
ATCC 23055, partial Acinetobacter calcoaceticus

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0021
-
-
Acinetobacter sp.
0.0039
-
ATCC 23055 Acinetobacter calcoaceticus
0.0043
-
ATCC 14987 Acinetobacter calcoaceticus
0.0063
-
-
Acinetobacter lwoffii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arogenate + NAD(P)+
-
Acinetobacter calcoaceticus L-tyrosine + NAD(P)H + CO2
-
?
L-arogenate + NAD(P)+
-
Acinetobacter sp. L-tyrosine + NAD(P)H + CO2
-
?
L-arogenate + NAD(P)+
-
Acinetobacter lwoffii L-tyrosine + NAD(P)H + CO2
-
?
L-arogenate + NAD(P)+
-
Acinetobacter sp. C1W L-tyrosine + NAD(P)H + CO2
-
?
L-arogenate + NAD+
-
Acinetobacter calcoaceticus L-tyrosine + NADH + CO2
-
?
L-arogenate + NAD+
-
Acinetobacter sp. L-tyrosine + NADH + CO2
-
?
L-arogenate + NAD+
-
Acinetobacter lwoffii L-tyrosine + NADH + CO2
-
?
L-arogenate + NAD+
-
Acinetobacter sp. C1W L-tyrosine + NADH + CO2
-
?

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Acinetobacter calcoaceticus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.009
-
L-tyrosine ATCC 23055, competitive inhibition Acinetobacter calcoaceticus