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Literature summary for 1.3.1.43 extracted from
- A single cyclohexadienyl dehydrogenase specifies the prephenate dehydrogenase and arogenate dehydrogenase components of the dual pathways to L-tyrosine in Pseudomonas aeruginosa (1990), J. Biol. Chem., 265, 20033-20036.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| L-tyrosine | competitive inhibition | Pseudomonas aeruginosa |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.07 | - |
prephenate | - |
Pseudomonas aeruginosa | |
| 0.17 | - |
L-arogenate | - |
Pseudomonas aeruginosa | |
| 0.25 | - |
NAD+ | - |
Pseudomonas aeruginosa | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 25500 | - |
6 * 25500, SDS-PAGE | Pseudomonas aeruginosa |
| 150000 | - |
gel filtration | Pseudomonas aeruginosa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-arogenate + NAD+ | Pseudomonas aeruginosa | - |
L-tyrosine + NADH + CO2 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas aeruginosa | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Pseudomonas aeruginosa |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-arogenate + NAD(P)+ | - |
Pseudomonas aeruginosa | L-tyrosine + NAD(P)H + CO2 | - |
? | |
| L-arogenate + NAD+ | - |
Pseudomonas aeruginosa | L-tyrosine + NADH + CO2 | - |
? | |
| additional information | activity with prephenate and L-arogenate is unseparable during purification, thus cyclohexadienyl dehydrogenase activity | Pseudomonas aeruginosa | ? | - |
? | |
| prephenate + NAD(P)+ | - |
Pseudomonas aeruginosa | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| hexamer | 6 * 25500, SDS-PAGE | Pseudomonas aeruginosa |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cyclohexadienyl dehydrogenase | - |
Pseudomonas aeruginosa |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NAD+ | - |
Pseudomonas aeruginosa | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.05 | - |
L-tyrosine | with L-arogenate as variable substrate, competitive inhibition | Pseudomonas aeruginosa | |
| 0.06 | - |
L-tyrosine | with prephenate as variable substrate, competitive inhibition | Pseudomonas aeruginosa | |
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