Literature summary for 1.3.1.22 extracted from

Xiao, Q.; Wang, L.; Supekar, S.; Shen, T.; Liu, H.; Ye, F.; Huang, J.; Fan, H.; Wei, Z.; Zhang, C.
Structure of human steroid 5alpha-reductase 2 with the anti-androgen drug finasteride (2020), Nat. Commun., 11, 5430 .

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Sf9 cell	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
structure of SRD5A2 with finasteride at 2.8 A, reveals a 7-TM structural topology and an intermediate adduct of finasteride and NADPH as NADP-dihydrofinasteride in a largely enclosed binding cavity inside the transmembrane domain. The molecular mechanisms of the reaction and of finasteride inhibition involve residues E57 and Y91. The cytosolic region that regulates NADPH/NADP+ exchange displays high conformational dynamics	Homo sapiens

Crystallization (Comment)

Organism

structure of SRD5A2 with finasteride at 2.8 A, reveals a 7-TM structural topology and an intermediate adduct of finasteride and NADPH as NADP-dihydrofinasteride in a largely enclosed binding cavity inside the transmembrane domain. The molecular mechanisms of the reaction and of finasteride inhibition involve residues E57 and Y91. The cytosolic region that regulates NADPH/NADP+ exchange displays high conformational dynamics

Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
dutasteride	-	Homo sapiens
finasteride	-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P31213	-	-

Synonyms

Synonyms	Comment	Organism
SRD5A2	-	Homo sapiens

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Release 2023.1 (January 2023)