Inhibitors | Comment | Organism | Structure |
---|---|---|---|
finasteride | 5alphaR2 inhibitor | Homo sapiens | |
MK386 | potent inhibitory effect on 5alphaR1 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Homo sapiens | 5737 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
26000 | - |
5alphaR1, SDS-PAGE | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
dermal papilla cell | from beard and axillary hair and frontal scalp hair | Homo sapiens | - |
fibroblast | - |
Homo sapiens | - |
follicular dermal papilla cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
progesterone + NADPH + H+ | - |
Homo sapiens | 5alpha-pregnan-3,20-dione + NADP+ | - |
? | |
testosterone + NADPH + H+ | - |
Homo sapiens | 17beta-hydroxy-5alpha-androstan-3-one + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
5alphaR1 | - |
Homo sapiens |
5alphaR2 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0005 | - |
- |
Homo sapiens | MK386 | |
0.008 | - |
- |
Homo sapiens | finasteride |