Literature summary for 1.3.1.20 extracted from

Deng, H.B.; Adikari, M.; Parekh, H.K.; Simpkins, H.
Ubiquitous induction of resistance to platinum drugs in human ovarian, cervical, germ-cell and lung carcinoma tumor cells overexpressing isoforms 1 and 2 of dihydrodiol dehydrogenase (2004), Cancer Chemother. Pharmacol., 54, 301-307.

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Inhibitors

Inhibitors	Comment	Organism	Structure
carboplatin	50% inhibition at 0.0358 mM, parental 2008 cell, at 0.578, 2008/C13* cell, at 0.0974 mM, 2008 cell expressing isoform 1, at 0.0871 mM, 2008 cell expressing isoform 2	Homo sapiens
cisplatin	50% inhibition at 0.0021 mM, parental 2008 cell, at 0.0186, 2008/C13* cell, at 0.0161 mM, 2008 cell expressing isoform 1, at 0.0062 mM, 2008 cell expressing isoform 2	Homo sapiens
doxorubicin hydrochloride	50% inhibition at 0.000706 mM, parental 2008 cell, at 0.000377, 2008/C13* cell, at 0.000375 mM, 2008 cell expressing isoform 2	Homo sapiens
melphalan	50% inhibition at 0.009 mM, parental 2008 cell, at 0.0088, 2008/C13* cell, at 0.0057 mM, 2008 cell expressing isoform 2	Homo sapiens
additional information	further values for other cell lines	Homo sapiens
paclitaxel	50% inhibition at 0.0000393 mM, parental 2008 cell, at 0.0000101, 2008/C13* cell, at 0.0000283 mM, 2008 cell expressing isoform 2	Homo sapiens
vincristine	50% inhibition at 0.000021 mM, parental 2008 cell, at 0.000016, 2008/C13* cell, at 0.0000136 mM, 2008 cell expressing isoform 2	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	Cell lines constitutively overexpressing enzyme isoform 1 or 2	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
carcinoma cell	ovarian carcinoma cell A2780 and SKOV-3, cisplatin-sensitive and cisplatin-resistant cell 2008 and 2008/C13*, cervical carcinoma cell A431, germ-cell tumor Tera-2, lung adenocarcinoma cell Calu-6	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	further values for more cell lines	Homo sapiens
0.0067	-	pH 7.4, cytosolic fraction of parental 2008 cell	Homo sapiens
0.0213	-	pH 7.4, cytosolic fraction of 2008 cell expressing isoform 2	Homo sapiens
0.0263	-	pH 7.4, cytosolic fraction of 2008 cell expressing isoform 1	Homo sapiens
0.0328	-	pH 7.4, cytosolic fraction of 2008/C13* cell	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-acenaphthol + NADP+	-	Homo sapiens	acenaphthylen-1-ol + NADPH	-	?

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Homo sapiens

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Release 2023.1 (January 2023)