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Literature summary for 1.3.1.20 extracted from

  • Matsuura, K.; Hara, A.; Deyashiki, Y.; Iwasa, H.; Kume, T.; Ishikura, S.; Shiraishi, H.; Katagiri, Y.
    Roles of the C-terminal domains of human dihydrodiol dehydrogenase isoforms in the binding of substrates and modulators: probing with chimeric enzymes (1998), Biochem. J., 336, 429-436.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
bezafibric acid DD4 Homo sapiens
Clofibric acid DD4, CDD4-1 Homo sapiens
fenofibric acid DD4, CDD4-1 Homo sapiens
Sulfobromophthalein DD4, CDD4-1 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
DD1, DD4, CDD1-4, CDD4-1, all expressed in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
C87S DD1 mutant Homo sapiens
L54V DD1 mutant, increase in activity towards (S)-indan-1-ol and bile-acids, increased Km for trans-benzene dihydrodiol Homo sapiens
additional information CDD1-4 mutant consisting of DD1 with C-terminal end of DD4 shows 10-37fold increase in Km for indan-1-ol and 1,2,3,4-tetrahydronaphth-1-ol and significantly decreased activity towards androstanes, higher activity with bile-acids and 5beta-steroid than DD1 Homo sapiens
additional information CDD4-1 mutant consisting of DD4 with C-terminal end of DD1shows new stereospecificity toward indan-1-ol stereomers and increased Km-values with bile acids and 3-hydroxysteroids compared to DD4 Homo sapiens
Q172L DD1 mutant Homo sapiens
R170H DD1 mutant Homo sapiens
R47H DD1 mutant Homo sapiens
T38V DD1 mutant Homo sapiens
V151M DD1 mutant Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1,10-phenanthroline recombinant: DD1, DD4, CDD1-4, CDD4-1 Homo sapiens
Betamethasone recombinant: DD1, DD4, CDD1-4, CDD4-1 Homo sapiens
Flufenamic acid recombinant: DD1, DD4, CDD1-4, CDD4-1 Homo sapiens
Hexestrol recombinant: DD1, DD4, CDD1-4, CDD4-1 Homo sapiens
indomethacin recombinant: DD1, DD4, CDD1-4, CDD4-1 Homo sapiens
Medroxyprogesterone acetate recombinant: DD1, DD4, CDD1-4, CDD4-1 Homo sapiens
Phenolphthalein recombinant: DD1, DD4, CDD1-4, CDD4-1 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
DD1, DD4
-

Purification (Commentary)

Purification (Comment) Organism
DD1, DD4, CDD1-4, CDD4-1, all recombinant from Escherichia coli Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(S)-indan-1-ol + NADP+ DD1, DD4, mutant CDD1-4, mutant CDD4-1 Homo sapiens ?
-
?

Cofactor

Cofactor Comment Organism Structure
NADP+
-
Homo sapiens