Activating Compound | Comment | Organism | Structure |
---|---|---|---|
bezafibric acid | DD4 | Homo sapiens | |
Clofibric acid | DD4, CDD4-1 | Homo sapiens | |
fenofibric acid | DD4, CDD4-1 | Homo sapiens | |
Sulfobromophthalein | DD4, CDD4-1 | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
DD1, DD4, CDD1-4, CDD4-1, all expressed in Escherichia coli | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C87S | DD1 mutant | Homo sapiens |
L54V | DD1 mutant, increase in activity towards (S)-indan-1-ol and bile-acids, increased Km for trans-benzene dihydrodiol | Homo sapiens |
additional information | CDD1-4 mutant consisting of DD1 with C-terminal end of DD4 shows 10-37fold increase in Km for indan-1-ol and 1,2,3,4-tetrahydronaphth-1-ol and significantly decreased activity towards androstanes, higher activity with bile-acids and 5beta-steroid than DD1 | Homo sapiens |
additional information | CDD4-1 mutant consisting of DD4 with C-terminal end of DD1shows new stereospecificity toward indan-1-ol stereomers and increased Km-values with bile acids and 3-hydroxysteroids compared to DD4 | Homo sapiens |
Q172L | DD1 mutant | Homo sapiens |
R170H | DD1 mutant | Homo sapiens |
R47H | DD1 mutant | Homo sapiens |
T38V | DD1 mutant | Homo sapiens |
V151M | DD1 mutant | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | recombinant: DD1, DD4, CDD1-4, CDD4-1 | Homo sapiens | |
Betamethasone | recombinant: DD1, DD4, CDD1-4, CDD4-1 | Homo sapiens | |
Flufenamic acid | recombinant: DD1, DD4, CDD1-4, CDD4-1 | Homo sapiens | |
Hexestrol | recombinant: DD1, DD4, CDD1-4, CDD4-1 | Homo sapiens | |
indomethacin | recombinant: DD1, DD4, CDD1-4, CDD4-1 | Homo sapiens | |
Medroxyprogesterone acetate | recombinant: DD1, DD4, CDD1-4, CDD4-1 | Homo sapiens | |
Phenolphthalein | recombinant: DD1, DD4, CDD1-4, CDD4-1 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
DD1, DD4 | - |
Purification (Comment) | Organism |
---|---|
DD1, DD4, CDD1-4, CDD4-1, all recombinant from Escherichia coli | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-indan-1-ol + NADP+ | DD1, DD4, mutant CDD1-4, mutant CDD4-1 | Homo sapiens | ? | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens |