Cloned (Comment) | Organism |
---|---|
DD1, expression in Escherichia coli | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | DD1, recombinant DD1, but DD2 less sensitive | Homo sapiens | |
1,7-phenanthroline | DD1, recombinant DD1, but DD2 less sensitive | Homo sapiens | |
chenodeoxycholic acid | DD2 very sensitive, DD1 less sensitive, recombinant DD1 | Homo sapiens | |
Flufenamic acid | DD1, DD2, recombinant DD1 | Homo sapiens | |
Hexestrol | DD1, DD2, recombinant DD1 | Homo sapiens | |
Ibuprofen | very sensitive: DD2, less sensitive: DD1, recombinant DD1 | Homo sapiens | |
indomethacin | DD1, DD2, recombinant DD1 | Homo sapiens | |
lithocholic acid | DD2, DD1, recombinant DD1 | Homo sapiens | |
Ursodeoxycholic acid | very sensitiv: DD2, less sensitiv: DD1, recombinant DD1 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q04828 | DD1, DD2 | - |
Purification (Comment) | Organism |
---|---|
DD1, recombinant from Escherichia coli | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
11 | - |
DD2 | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(S)-indan-1-ol + NADP+ | recombinant DD1, DD1, DD2 | Homo sapiens | ? | - |
? | |
(S)-tetralol + NADP+ | DD1, DD2, recombinant DD1 | Homo sapiens | ? | - |
? | |
5beta-androstan-3alpha,17beta-diol + NADP+ | DD1, DD2, recombinant DD1 | Homo sapiens | 5beta-androstan-3,17-dione + NADPH | - |
? | |
5beta-pregnan-3,20-diol + NADP+ | DD1, DD2, recombinant DD1 | Homo sapiens | 5beta-pregnan-20-ol-3-one + NADPH | - |
? | |
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ | DD1, DD2, recombinant DD1 | Homo sapiens | catechol + NAD(P)H | - |
? |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0317 | - |
trans-benzene dihydrodiol | DD2 | Homo sapiens | |
0.0533 | - |
trans-benzene dihydrodiol | DD1 | Homo sapiens | |
0.145 | - |
trans-benzene dihydrodiol | recombinant DD1 | Homo sapiens | |
0.158 | - |
(S)-indan-1-ol | DD2 | Homo sapiens | |
0.167 | - |
(S)-indan-1-ol | DD1 | Homo sapiens | |
0.417 | - |
(S)-indan-1-ol | DD1 recombinant | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | - |
Homo sapiens | |
NADPH | - |
Homo sapiens |