Activating Compound | Comment | Organism | Structure |
---|---|---|---|
NaCl | DD3 | Cavia porcellus | |
potassium phosphate | - |
Cavia porcellus | |
SO42- | - |
Cavia porcellus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Barbital | DD2, DD4 | Cavia porcellus | |
Hexestrol | - |
Cavia porcellus | |
indomethacin | - |
Cavia porcellus | |
NaCl | DD2, DD4 | Cavia porcellus | |
p-chloromercuriphenyl sulfonate | inhibits only DD3 | Cavia porcellus | |
quercitrin | - |
Cavia porcellus | |
sorbinil | DD2, DD3 is more sensitive, DD4 no inhibition | Cavia porcellus | |
Stilbestrol | - |
Cavia porcellus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
30000 | - |
about, DD2-DD4. gel filtration | Cavia porcellus |
32000 | - |
1 * 32000, DD3, and 1 * 36000, DD4, SDS-PAGE | Cavia porcellus |
36000 | - |
1 * 32000, DD3, and 1 * 36000, DD4, SDS-PAGE | Cavia porcellus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ | Cavia porcellus | - |
catechol + NAD(P)H | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Cavia porcellus | - |
3 forms: DD2 pI form 5.4, DD3 pI 5.0 form, and DD4 pI 4.2 form | - |
Purification (Comment) | Organism |
---|---|
- |
Cavia porcellus |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
trans-1,2-dihydrobenzene-1,2-diol + NADP+ = catechol + NADPH + H+ | probably identical with D-xylose dehydrogenase EC 1.1.1.179 | Cavia porcellus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
testis | - |
Cavia porcellus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Cavia porcellus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-carboxybenzaldehyde + NADPH | - |
Cavia porcellus | ? | - |
? | |
4-nitrobenzaldehyde + NAD(P)H | DD2, DD3 | Cavia porcellus | 4-nitrobenzylalcohol + NAD(P)+ | - |
? | |
alicyclic alcohol + NAD(P)+ | not: | Cavia porcellus | ? | - |
? | |
D-galactose + NADP+ | only isoform DD3 | Cavia porcellus | D-galactono-1,5-lactone + NADPH | - |
? | |
D-glucose + NADP+ | only isoform DD3 | Cavia porcellus | D-glucono-1,5-lactone + NADPH + H+ | - |
? | |
D-glucuronate + NADP+ | isoform DD4 no activity | Cavia porcellus | D-glucurono-1,5-lactone + NADPH | - |
r | |
D-glyceraldehyde + NADPH | DD2 and DD3 show high activity, DD4 only shows low activity | Cavia porcellus | ? | - |
? | |
D-xylose + NADP+ | - |
Cavia porcellus | D-xylono-1,5-lactone + NADPH + H+ | - |
? | |
diacetyl + NADPH | - |
Cavia porcellus | ? | - |
? | |
L-glyceraldehyde + NADPH | DD2 and DD3 show high activity, DD4 only shows low activity | Cavia porcellus | ? | - |
? | |
additional information | not: hydroxy steroids | Cavia porcellus | additional information | - |
? | |
additional information | xenobiotic acyclic alcohols (Japanese monkey) | Cavia porcellus | additional information | - |
? | |
additional information | 3 forms: DD4 pI 4.2, DD3 pI 5.0 and DD2 pI 5.4, isoform DD4: strict specificity for benzene dihydrodiol and NADP+, and for reduced pyridine aldehydes, glyceraldehyde and, at low rate, for diacetyl, isoform DD3: oxidizes n-butanol, glycerol and sorbitol as well as benzene dihydrodiol in the presence of NADP+ or NAD+, and exhibits much higher reductase activity towards various aldehydes, aldoses and diacetyl | Cavia porcellus | additional information | - |
? | |
pyridine-3-aldehyde + NADPH | - |
Cavia porcellus | ? | - |
? | |
pyridine-4-aldehyde + NADPH | - |
Cavia porcellus | ? | - |
? | |
succinic semialdehyde + NADPH | isoform DD4 low activity | Cavia porcellus | ? | - |
? | |
trans-1,2-dihydrobenzene-1,2-diol + NAD(P)+ | - |
Cavia porcellus | catechol + NAD(P)H | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | 1 * 32000, DD3, and 1 * 36000, DD4, SDS-PAGE | Cavia porcellus |
Synonyms | Comment | Organism |
---|---|---|
DD | - |
Cavia porcellus |
dihydrodiol dehydrogenase | - |
Cavia porcellus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADP+ | dependent on, DD2 and DD4 nearly no activity with NAD+ | Cavia porcellus | |
NADPH | - |
Cavia porcellus |