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Literature summary for 1.2.3.1 extracted from

  • Montefiori, M.; Jorgensen, F.S.; Olsen, L.
    Aldehyde oxidase reaction mechanism and prediction of site of metabolism (2017), ACS Omega, 2, 4237-4244 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.2.3.1

Organism

Organism UniProt Comment Textmining
Homo sapiens Q06278
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
famciclovir + H2O + O2
-
 Homo sapiens ? + H2O2
-
 ?
N-[2-(dimethylamino)ethyl]acridine-4-carboxamide + H2O + O2
-
 Homo sapiens N-[(2-dimethylamino)ethyl] acridine-4-carboxamide-9(10H)-acridone + H2O2
-
 ?
phenanthridine + H2O + O2
-
 Homo sapiens 6-phenanthridone + H2O2
-
 ?
phthalazine + H2O + O2
-
 Homo sapiens 1-phthalazinone + H2O2
-
 ?
quinazoline + H2O + O2
-
 Homo sapiens ? + H2O2
-
 ?
quinoline + H2O + O2
-
 Homo sapiens ? + H2O2
-
 ?

Synonyms

Synonyms Comment Organism
AOX1
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism density functional theory using the molybdenum cofactor as a model to study structural and energetic aspects of different mechanisms. For a series of 6-substituted 4-quinazolinones, the trend in activation energies is the same for three tested reaction mechanisms. During the transition states for the formation of all possible metabolites for a series of known substrates, the lowest activation energies correspond in all cases to the experimentally observed sites of metabolism Homo sapiens