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Literature summary for 1.2.1.105 extracted from

  • Parker, M.G.; Weitzman, P.D.J.
    The purification and regulatory properties of alpha-oxoglutarate dehydrogenase from Acinetobacter lwoffi (1973), Biochem. J., 135, 215-223.
    View publication on PubMedView publication on EuropePMC
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Activating Compound

Activating Compound Comment Organism Structure
ADP stimulates 2-oxoglutarate dehydrogenase complex Acinetobacter lwoffii
AMP stimulates 2-oxoglutarate dehydrogenase complex Acinetobacter lwoffii

Inhibitors

Inhibitors Comment Organism Structure
NADH 2-oxoglutarate dehydrogenase complex Acinetobacter lwoffii

Organism

Organism UniProt Comment Textmining
Acinetobacter lwoffii
-
-
-

Purification (Commentary)

Purification (Comment) Organism
2-oxoglutarate dehydrogenase complex Acinetobacter lwoffii

Reaction

Reaction Comment Organism Reaction ID
2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2 the enzyme complex catalyzes the reaction : 2-oxoglutarate + CoA + NAD+--> succinyl-CoA + CO2 + NADH, the following partial reactions are catalyzed: 1. HOOC(CH2)2COCOOH + (thiamine diphosphate)-E1--> (HOOC(CH2)2 CHOH-thiamine-diphosphate)-E1 + CO2, 2. (HOOC(CH2)2CH OH-thiamine-diphosphate)-E1 + (LipS2)-E2--> (HOOC(CH)2 CO-(SLipSH))-E2 + (thiamine-diphosphate)-E1, 3. (HOOC(CH2)2CO-(SLipSH))-E2 + HSCoA--> (Lip(SH)2)-E2 + HOOC(CH2)2CO-SCoA, 4. (Lip(SH)2)-E2 + E3-FAD--> (LipS2)-E2 + reduced E3-FAD, 5. reduced E3-FAD + NAD+--> E3-FAD + NADH Acinetobacter lwoffii
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2-oxoglutarate + lipoamide
-
 Acinetobacter lwoffii S-succinyldihydrolipoamide + CO2
-
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