Protein Variants | Comment | Organism |
---|---|---|
M131A | mutation in the peripheral subunit-binding domain of the E2 chain. Residue M131 makes a significant contribution to the binding of pyruvate decarboxylase E1. Mutation lowers the binding affinity for pyruvate decarboxylase E1 by almost 140fold | Geobacillus stearothermophilus |
additional information | residues K136, K153, R146, S133 do not contribute to the interaction with pyruvate decarboxylase E1 | Geobacillus stearothermophilus |
R135A | mutation in the peripheral subunit-binding domain of the E2 chain, lowers the binding affinity for pyruvate decarboxylase E1 by almost 140fold | Geobacillus stearothermophilus |
R135C | mutation in the peripheral subunit-binding domain of the E2 chain, plays an important part in the interaction with both pyruvate decarboxylase E1 and dihydrolipoyl dehydrogenase E3 | Geobacillus stearothermophilus |
R135K | mutant behaves almost like the wild-type | Geobacillus stearothermophilus |
R156A | mutation in the peripheral subunit-binding domain of the E2 chain, lowers the binding affinity for pyruvate decarboxylase E1 by almost 19fold | Geobacillus stearothermophilus |
Organism | UniProt | Comment | Textmining |
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Geobacillus stearothermophilus | - |
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