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Literature summary for 1.2.1.104 extracted from

  • Harding, R.W.; Caroline, D.F.; Wagner, R.P.
    The pyruvate dehydrogenase complex from the mitochondrial fraction of Neurospora crassa (1970), Arch. Biochem. Biophys., 138, 653-661.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
citrate 0.25 mM, 29% inhibition, 50.0 mM, 87% inhibition Neurospora crassa
MgATP2-
-
Neurospora crassa

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.017
-
pyruvate similar values Neurospora crassa

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ no requirement Neurospora crassa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pyruvate + lipoamide Neurospora crassa in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by 2-ketobutyrate S-acetyldihydrolipoamide + CO2
-
?
pyruvate + lipoamide Neurospora crassa additional reactions of complex, e. g. reduction of K3Fe(CN)6 S-acetyldihydrolipoamide + CO2
-
?

Organism

Organism UniProt Comment Textmining
Neurospora crassa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
pyruvate + lipoamide in overall reaction of pyruvate dehydrogenase complex, pyruvate can be replaced by 2-ketobutyrate Neurospora crassa S-acetyldihydrolipoamide + CO2
-
?
pyruvate + lipoamide additional reactions of complex, e. g. reduction of K3Fe(CN)6 Neurospora crassa S-acetyldihydrolipoamide + CO2
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
value for pyruvate dehydrogenase complex: 8.0-9.0 Neurospora crassa

Cofactor

Cofactor Comment Organism Structure
thiamine diphosphate
-
Neurospora crassa