Literature summary for 1.2.1.104 extracted from

Bresters, T.W.; de Abreu, R.A.; de Kok, A.; Visser, J.; Veeger, C.
The pyruvate-dehydrogenase complex from Azotobacter vinelandii (1975), Eur. J. Biochem., 59, 335-345.

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Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Sus scrofa
Mg2+	-	Azotobacter vinelandii

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
pyruvate + lipoamide	Sus scrofa	-	S-acetyldihydrolipoamide + CO2	-	?
pyruvate + lipoamide	Escherichia coli	additional reactions of complex, e. g. reduction of K3Fe(CN)6	S-acetyldihydrolipoamide + CO2	-	?
pyruvate + lipoamide	Azotobacter vinelandii	additional reactions of complex, e. g. reduction of K3Fe(CN)6	S-acetyldihydrolipoamide + CO2	-	?

Organism

Organism	UniProt	Comment	Textmining
Azotobacter vinelandii	-	-	-
Escherichia coli	-	-	-
Sus scrofa	-	-	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.085	-	pyruvate-K3Fe(CN)6 reductase assay	Sus scrofa
0.14	-	pyruvate-K3Fe(CN)6 reductase assay	Sus scrofa
0.2	-	pyruvate-K3Fe(CN)6 reductase assay	Escherichia coli

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pyruvate + lipoamide	-	Sus scrofa	S-acetyldihydrolipoamide + CO2	-	?
pyruvate + lipoamide	additional reactions of complex, e. g. reduction of K3Fe(CN)6	Escherichia coli	S-acetyldihydrolipoamide + CO2	-	?
pyruvate + lipoamide	additional reactions of complex, e. g. reduction of K3Fe(CN)6	Azotobacter vinelandii	S-acetyldihydrolipoamide + CO2	-	?

Cofactor

Cofactor	Comment	Organism	Structure
thiamine diphosphate	-	Escherichia coli
thiamine diphosphate	-	Sus scrofa
thiamine diphosphate	-	Azotobacter vinelandii

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Release 2023.1 (January 2023)