Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,2'-dipyridyl | 99.0% inhibition at 1.0 mM using L-phenylalanine as substrate, 99.0% inhibition at 1.0 mM using S-carboxymethyl-L-cysteine as substrate | Homo sapiens | |
3-iodotyrosine | 3.0% inhibition at 1.0 mM using L-phenylalanine as substrate, 5.2% inhibition at 1.0 mM using S-carboxymethyl-L-cysteine as substrate | Homo sapiens | |
4-Chlorophenylalanine | specific PAH inhibitor, 97.2% inhibition at 1.0 mM using L-phenylalanine as substrate, 99.2% inhibition at 1.0 mM using S-carboxymethyl-L-cysteine as substrate | Homo sapiens | |
6-Fluorotryptophan | 2.5% inhibition at 1.0 mM using L-phenylalanine as substrate, 4.5% inhibition at 1.0 mM using S-carboxymethyl-L-cysteine as substrate | Homo sapiens | |
L-phenylalanine | competitive inhibition of the S-oxidation of S-carboxymethyl-L-cysteine, 92.8% inhibition at 1.0 mM using S-carboxymethyl-L-cysteine as substrate | Homo sapiens | |
additional information | not inhibited by the nitric oxide synthase inhibitors N(G)-monomethyl-D-arginine, 7-nitroindazole, L-thiocitrulline, N(G)-monomethyl-L-arginine, (S)-methy-L-thiocitrulline, and L-N5-(1-iminoethyl)ornithine; PH8, the large aromatic amino acid hydroxylase monoclonal antibody, inhibits the production of both L-tyrosine and S-carboxymethyl-L-cysteine S-oxide to 99.0% and 99.3% at 0.2 mg/ml concentration | Homo sapiens | |
S-carboxymethyl-L-cysteine | competitive inhibitor of the aromatic C-oxidation of L-phenylalanine, 25.2% inhibition at 5.0 mM using L-phenylalanine as substrate | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0231 | - |
5,6,7,8-tetrahydrobiopterin | using L-phenylalanine as cosubstrate, in pooled hepatic cytosolic enzyme fraction, at 37°C | Homo sapiens | |
0.02333 | - |
5,6,7,8-tetrahydrobiopterin | using L-phenylalanine as cosubstrate, in pooled hepatic cytosolic enzyme fraction activated with 1 mM lysophosphatidylcholine, at 37°C | Homo sapiens | |
0.07312 | - |
5,6,7,8-tetrahydrobiopterin | using S-carboxymethyl-L-cysteine as cosubstrate, in pooled hepatic cytosolic enzyme fraction activated with 1 mM lysophosphatidylcholine, at 37°C | Homo sapiens | |
0.07812 | - |
5,6,7,8-tetrahydrobiopterin | using S-carboxymethyl-L-cysteine as cosubstrate, in pooled hepatic cytosolic enzyme fraction, at 37°C | Homo sapiens | |
0.16 | - |
L-phenylalanine | in pooled hepatic cytosolic enzyme fraction activated with 1 mM lysophosphatidylcholine, at 37°C | Homo sapiens | |
3.05 | - |
L-phenylalanine | in pooled hepatic cytosolic enzyme fraction, at 37°C | Homo sapiens | |
16.22 | - |
S-carboxymethyl-L-cysteine | - |
Homo sapiens | |
16.53 | - |
S-carboxymethyl-L-cysteine | in pooled hepatic cytosolic enzyme fraction activated with 1 mM lysophosphatidylcholine, at 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-phenylalanine + 5,6,7,8-tetrahydrobiopterin + O2 | - |
Homo sapiens | L-tyrosine + 4a-hydroxytetrahydrobiopterin | - |
? | |
S-carboxymethyl-L-cysteine + 5,6,7,8-tetrahydrobiopterin + O2 | - |
Homo sapiens | S-carboxymethyl-L-cysteine S-oxide + dihydrobiopterin + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAH | - |
Homo sapiens |
phenylalanine hydroxylase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
5,6,7,8-tetrahydro-L-biopterin | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
17.23 | - |
S-carboxymethyl-L-cysteine | in pooled hepatic cytosolic enzyme fraction, at 37°C | Homo sapiens |