Cloned (Comment) | Organism |
---|---|
gene CYP46A1, quantitative expression analysis | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
voriconazole | voriconazole decreases 24S-hydroxycholesterol levels in the retina. CYP46A1 expression is increased in the retina of voriconazole-treated rats. Intercellular adhesion molecule 1 (ICAM-1) and monocyte chemotactic protein 1 (MCP-1) show significant increases in the retina and vitreous body. Minocycline did not reverse the effects of voriconazole | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | Rattus norvegicus | - |
(24S)-cholest-5-ene-3beta,24-diol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | Rattus norvegicus Wistar | - |
(24S)-cholest-5-ene-3beta,24-diol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | F7EN52 | gene CYP46A1 | - |
Rattus norvegicus Wistar | F7EN52 | gene CYP46A1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
central nervous system | - |
Rattus norvegicus | - |
neuron | - |
Rattus norvegicus | - |
retina | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus | (24S)-cholest-5-ene-3beta,24-diol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? | |
cholesterol + [reduced NADPH-hemoprotein reductase] + O2 | - |
Rattus norvegicus Wistar | (24S)-cholest-5-ene-3beta,24-diol + [oxidized NADPH-hemoprotein reductase] + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
cholesterol 24S-hydroxylase | - |
Rattus norvegicus |
cholesterol-24S-hydroxylase | - |
Rattus norvegicus |
CYP46A1 | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | CYP46A1 expression is increased in the retina of voriconazole-treated rats | up |
General Information | Comment | Organism |
---|---|---|
physiological function | cholesterol 24S-hydroxylase converts cholesterol into 24S-hydroxycholesterol in neurons and participates in cholesterol homeostasis in the central nervous system, including the retina | Rattus norvegicus |