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Literature summary for 1.14.13.9 extracted from

  • Morita, N.; Hoshi, M.; Hara, T.; Ninomiya, S.; Enoki, T.; Yoneda, M.; Tsurumi, H.; Saito, K.
    Viability of diffuse large B-cell lymphoma cells is regulated by kynurenine 3-monooxygenase activity (2021), Oncol. Lett., 22, 790 .
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene kmo, quantitative reverse transcription-PCR enzyme expression analysis Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial outer membrane
-
 Homo sapiens 5741
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-kynurenine + NADPH + H+ + O2 Homo sapiens
-
 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O15229
-
-

Source Tissue

Source Tissue Comment Organism Textmining
KML-1 cell showing low levels of KMO expression (KMOlow) Homo sapiens
-
STR-428 cell showing high levels of KMO expression (KMOhigh) Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-kynurenine + NADPH + H+ + O2
-
 Homo sapiens 3-hydroxy-L-kynurenine + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
KMO
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Homo sapiens
NADPH
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction diffuse large B-cell lymphoma (DLBCL) is a clinically heterogeneous lymphoid malignancy and a clinically heterogeneous lymphoid malignancy that is the most common type of lymphoma in Japan, patients with DLBCL have a poor progxadnosis due to increased levels of indoleamine 2,3-dioxygnase and kynurenine (KYN). Serum 3-hydroxy-L-kynurenine (3-HK) levels are regulated independently of serum KYN levels, and increased serum 3-HK levels and KMO activity are associated with worse disease progression. The addition of KMO inhibitors and 3-HK negatively and positively regulate the viability of DLBCL cells, respectively. NAD+ levels in high-KMO-expression-level KMOhigh STR-428 cells are significantly higher than those in low-KMO-expression-level KMOlow KML-1 cells. These results suggest that 3-HK generated by KMO activity may be involved in the regulation of DLBCL cell viability via NAD+ synthesis Homo sapiens
physiological function viability of diffuse large B-cell lymphoma cells is regulated by kynurenine 3-monooxygenase activity Homo sapiens