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Literature summary for 1.14.13.8 extracted from
- Hepatic flavin-containing monooxygenase and aldehyde oxidase activities in male domestic pigs at different ages (2018), Drug Metab. Lett., 12, 125-131 .
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | Michaelis-Menten kinetics | Sus scrofa |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Sus scrofa | 16020 | - |
| microsome | - |
Sus scrofa | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzydamine + NADPH + H+ + O2 | Sus scrofa | - |
benzydamine N-oxide + NADP+ + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | FMO activity is substantial in the liver microsomes of one-day-old neonatal pigs. This activity increases rapidly in 2 weeks of growth and then remains high. The highest porcine hepatic FMO activity is detected at the age of 20 weeks. Since both liver and body weight increase during the growth of pigs, the growth impact on the hepatic FMO activity is also assessed using in vivo intrinsic clearance of benzydamine N-oxidation at different ages. Although the highest in vivo intrinsic clearance is still at around 2-5 weeks age, the clearance is reduced at age of 20 weeks obviously | Sus scrofa | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| benzydamine + NADPH + H+ + O2 | - |
Sus scrofa | benzydamine N-oxide + NADP+ + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| flavin-containing monooxygenase | - |
Sus scrofa |
| FMO | - |
Sus scrofa |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Sus scrofa |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Sus scrofa |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Sus scrofa | |
| NADPH | - |
Sus scrofa | |
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