Protein Variants | Comment | Organism |
---|---|---|
additional information | construction of Fmo1-/-, 2-/-, and 4-/- knockout mutants, 1D 1H NMR spectroscopy to compare the urinary metabolite profiles of the knockout-mouse line and wild-type animals, metabolic profiles of hypotaurine and taurine in wild-type and mutant mice' urine samples, overview | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Homo sapiens | 16020 | - |
membrane | - |
Mus musculus | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
hypotaurine + NADH + H+ + O2 | Homo sapiens | S-oxygenation | taurine + NAD+ + H2O | - |
? | |
hypotaurine + NADH + H+ + O2 | Mus musculus | S-oxygenation | taurine + NAD+ + H2O | - |
? | |
hypotaurine + NADPH + H+ + O2 | Homo sapiens | S-oxygenation | taurine + NADP+ + H2O | - |
? | |
hypotaurine + NADPH + H+ + O2 | Mus musculus | S-oxygenation | taurine + NADP+ + H2O | - |
? | |
N,N-dimethylaniline + NADPH + H+ + O2 | Homo sapiens | - |
N,N-dimethylaniline N-oxide + NADP+ + H2O | - |
? | |
N,N-dimethylaniline + NADPH + H+ + O2 | Mus musculus | - |
N,N-dimethylaniline N-oxide + NADP+ + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Homo sapiens | Q01740 | - |
- |
Mus musculus | P50285 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
hypotaurine + NADH + H+ + O2 | S-oxygenation | Homo sapiens | taurine + NAD+ + H2O | - |
? | |
hypotaurine + NADH + H+ + O2 | S-oxygenation | Mus musculus | taurine + NAD+ + H2O | - |
? | |
hypotaurine + NADPH + H+ + O2 | S-oxygenation | Homo sapiens | taurine + NADP+ + H2O | - |
? | |
hypotaurine + NADPH + H+ + O2 | S-oxygenation | Mus musculus | taurine + NADP+ + H2O | - |
? | |
hypotaurine + O2 + NADH + H+ | - |
Homo sapiens | taurine + NAD+ + H2O | - |
? | |
hypotaurine + O2 + NADPH + H+ | - |
Homo sapiens | taurine + NADP+ + H2O | - |
? | |
methimazole + NADH + H+ | - |
Homo sapiens | ? | - |
? | |
methimazole + NADPH + H+ | - |
Homo sapiens | ? | - |
? | |
methimazole + NADPH + H+ + O2 | S-oxygenation | Homo sapiens | methimazole S-oxide + NADP+ + H2O | - |
? | |
methimazole + NADPH + H+ + O2 | S-oxygenation | Mus musculus | methimazole S-oxide + NADP+ + H2O | - |
? | |
additional information | human FMO1 catalyzes the oxygenation of hypotaurine in vitro. Ability of hypotaurine to act as a competitor substrate of FMO1 is assessed by measuring the effect of various concentrations of hypotaurine on FMO1-catalyzed S-oxygenation of methimazole | Homo sapiens | ? | - |
- |
|
N,N-dimethylaniline + NADPH + H+ + O2 | - |
Homo sapiens | N,N-dimethylaniline N-oxide + NADP+ + H2O | - |
? | |
N,N-dimethylaniline + NADPH + H+ + O2 | - |
Mus musculus | N,N-dimethylaniline N-oxide + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
flavin-containing monooxygenase 1 | - |
Homo sapiens |
flavin-containing monooxygenase 1 | - |
Mus musculus |
FMO1 | - |
Homo sapiens |
FMO1 | - |
Mus musculus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
37 | - |
assay at | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8.5 | - |
assay at | Homo sapiens |
8.5 | - |
assay at | Mus musculus |
8.5 | - |
most active at pH 8.5 with NADPH as cofactor | Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens | |
FAD | - |
Mus musculus | |
additional information | enzyme FMO1 can use either NADPH or NADH as cofactor | Homo sapiens | |
additional information | enzyme FMO1 can use either NADPH or NADH as cofactor | Mus musculus | |
NADH | - |
Homo sapiens | |
NADH | - |
Mus musculus | |
NADH | whereas NADPH is the more effective cofactor at pH 8.5, the cofactors are equally effective at pH 7.4 | Homo sapiens | |
NADPH | - |
Homo sapiens | |
NADPH | - |
Mus musculus | |
NADPH | whereas NADPH is the more effective cofactor at pH 8.5, the cofactors are equally effective at pH 7.4 | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | FMO1 malfunction causes taurine deficiency, which is implicated in a number of pathologic conditions, including cardiomyopathy, muscular abnormalities, and renal dysfunction | Homo sapiens |
malfunction | FMO1 malfunction causes taurine deficiency, which is implicated in a number of pathologic conditions, including cardiomyopathy, muscular abnormalities, and renal dysfunction | Mus musculus |
physiological function | the formation of taurine from hypotaurine is catalyzed by an FMO in vivo, it is the terminal step of the biosynthetic pathway of taurine production from cysteine | Homo sapiens |
physiological function | the formation of taurine from hypotaurine is catalyzed by an FMO in vivo, it is the terminal step of the biosynthetic pathway of taurine production from cysteine | Mus musculus |