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Literature summary for 1.14.13.8 extracted from

  • Cheropkina, H.; Catucci, G.; Marucco, A.; Fenoglio, I.; Gilardi, G.; Sadeghi, S.
    Human flavin-containing monooxygenase 1 and its long-sought hydroperoxyflavin intermediate (2021), Biochem. Pharmacol., 193, 114763 .
    View publication on PubMed
Search for more literature for 1.14.13.8

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N,N-dimethylaniline + NADPH + H+ + O2 Homo sapiens
-
 N,N-dimethylaniline N-oxide + NADP+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q01740
-
-

Reaction

Reaction Comment Organism Reaction ID
N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O formation of a highly stable C4a-hydroperoxyflavin intermediate of hFMO1 upon reduction by NADPH in presence of O2 Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information formation of a highly stable C4a-hydroperoxyflavin intermediate of hFMO1 upon reduction by NADPH in presence of O2, the intermediate is not fully re-oxidized after 30 min at 15°C in the absence of substrate. The enzyme is below 1% uncoupled in the presence of substrate. Higher stability of the hFMO1 intermediate compared to the stability of the intermediate of isozyme hFMO3 Homo sapiens ?
-
-
N,N-dimethylaniline + NADPH + H+ + O2
-
 Homo sapiens N,N-dimethylaniline N-oxide + NADP+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
dimethylaniline monooxygenase [N-oxide-forming] 1 UniProt Homo sapiens
flavin-containing monooxygenase 1
-
 Homo sapiens
FMO1
-
 Homo sapiens
hFMO1
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Homo sapiens
NADPH
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function human FMO isozymes FMO1 and FMO3 are the most relevant to Phase I drug metabolism of all human isozymes. They are involved in the oxygenation of xenobiotics including drugs and pesticides Homo sapiens