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Literature summary for 1.14.13.8 extracted from

  • Chiba, K.; Kobayashi, K.; Itoh, K.; Itoh, S.; Chiba, T.; Ishizaki, T.; Kamataki, T.
    N-oxygenation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by the rat liver flavin-containing monooxygenase expressed in yeast cells (1995), Eur. J. Pharmacol., 293, 97-100.
    View publication on PubMed
Search for more literature for 1.14.13.8

Activating Compound

Activating Compound Comment Organism Structure
n-octylamine 3 mM, enhances activity by 51% Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
expression in yeast cells Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
alpha-naphthylthiourea 0.5 mM, 59.2% inhibition Rattus norvegicus
Methimazole 0.5 mM, 27.4% inhibition Rattus norvegicus
thiobenzamide 0.5 mM, 68% inhibition Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0018
-
 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + NADPH + H+ + O2 Rattus norvegicus one of the predominant enzmyes responsible for the oxygenation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide + NADP+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + NADPH + H+ + O2
-
 Rattus norvegicus 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide + NADP+ + H2O
-
 ?
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine + NADPH + H+ + O2 one of the predominant enzmyes responsible for the oxygenation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Rattus norvegicus 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine N-oxide + NADP+ + H2O
-
 ?

Cofactor

Cofactor Comment Organism Structure
flavin flavoprotein Rattus norvegicus