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Literature summary for 1.14.13.50 extracted from

  • Orser, C.S.; Lange, C.C.; Xun, L.; Zahrt, T.C.; Schneider, B.J.
    Cloning, sequence analysis, and expression of the Flavobacterium pentachlorophenol-4-monooxygenase gene in Escherichia coli (1993), J. Bacteriol., 175, 411-416.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
pcpB gene, constitutive overexpression in Escherichia coli, DNA sequence determination and analysis Flavobacterium sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
pentachlorophenol + 2 NADPH + H+ + O2 Flavobacterium sp. wild-type and transformed E. coli cells tetrachlorohydroquinone + 2 NADP+ + Cl- + H2O
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 ?

Organism

Organism UniProt Comment Textmining
Flavobacterium sp. P42535 strain ATCC 39723
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Flavobacterium sp. P42535 inducible by PCP on DNA level
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information enzyme also removes amino, cyano and nitro groups from the para-position to the hydroxyl group of the phenol Flavobacterium sp. ?
-
 ?
pentachlorophenol + 2 NADPH + H+ + O2 wild-type and transformed E. coli cells Flavobacterium sp. tetrachlorohydroquinone + 2 NADP+ + Cl- + H2O
-
 ?
pentachlorophenol + NADPH + H+ + O2
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 Flavobacterium sp. 2,3,5,6-tetrachlorohydroquinone + NADP+ + chloride + H2O
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 ?

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Flavobacterium sp.