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Literature summary for 1.14.13.39 extracted from

  • Marquet, N.; Canario, A.; Power, D.
    Localization and distribution of nitric oxide synthase and other neuronal markers in the podia of Holothuria arguinensis (2020), Invertebr. Biol., 139, e12298 .
No PubMed abstract available
Search for more literature for 1.14.13.39

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 Holothuria arguinensis overall reaction 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
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Organism

Organism UniProt Comment Textmining
Holothuria arguinensis
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 collected in the intertidal zone of the Ria Formosa in Faro (Portugal)
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Source Tissue

Source Tissue Comment Organism Textmining
body wall
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 Holothuria arguinensis
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brain stem
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 Holothuria arguinensis
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buccal nerve
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 Holothuria arguinensis
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bud main nervous structures (buccal nerve and nerve plate) in the bud of the tentacle Holothuria arguinensis
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central nervous system
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 Holothuria arguinensis
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longitudinal buccal nerve
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 Holothuria arguinensis
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mesothelium
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 Holothuria arguinensis
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additional information localization and distribution of nitric oxide synthase and other neuronal markers in the podia of Holothuria arguinensis, detailed overview. The podia terminal end is the most specialized area and is characterized by a specific nervous arrangement, consisting of a distinct nerve plate, rich in cells and fibers containing potential sensory cells staining positively for neuronal markers. In sea cucumbers, cells with morphological characteristics typical of sensory cells have been described in the tentacles, tube feet, and papillae. NADPH-diaphorase histochemistry and NOS immunohistochemistry. The NADPH-diaphorase staining and the anti-NOS antibody show an overall similar distribution in the tentacle. In the stem, the longitudinal buccal nerve and the buccal nerve are strongly reactive to both markers. The mesothelium is also positive for NADPH-d and anti-NOS. In the bud, the two methods reveal that NOS is present in both the buccal nerve and mesothelium Holothuria arguinensis
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neuron
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 Holothuria arguinensis
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papilla
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 Holothuria arguinensis
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peripheral nervous system
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 Holothuria arguinensis
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radial nerve cord
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 Holothuria arguinensis
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tentacle main nervous structures (buccal nerve and nerve plate) in the bud of the tentacle Holothuria arguinensis
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tube feet
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 Holothuria arguinensis
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 overall reaction Holothuria arguinensis 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
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 ?

Synonyms

Synonyms Comment Organism
nitric oxide synthase
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 Holothuria arguinensis
NOS
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 Holothuria arguinensis

Cofactor

Cofactor Comment Organism Structure
NADPH
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 Holothuria arguinensis

General Information

General Information Comment Organism
physiological function nitric oxide (NO) is synthesized from L-arginine by the NADPH-dependent enzyme nitric oxide synthase (NOS), and is involved in many essential biological functions including immune defense, vascular regulation, muscle relaxation, and neuromodulation, and neurotransmission Holothuria arguinensis