Literature summary for 1.14.13.39 extracted from

Yan, T.; Kong, Y.; Fan, W.; Kang, J.; Chen, H.; He, H.; Huang, F.
Expression of nitric oxide synthases in rat odontoblasts and the role of nitric oxide in odontoblastic differentiation of rat dental papilla cells (2021), Dev. Growth Differ., 63, 354-371 .

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Cloned(Commentary)

Cloned (Comment)	Organism
gene nos1, quantitative reverse-transcription PCR enzyme expression analysis	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
L-NG-monomethyl arginine	L-NMMA	Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2 L-arginine + 3 NADPH + 3 H+ + 4 O2	Rattus norvegicus	overall reaction	2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O	-	?
2 L-arginine + 3 NADPH + 3 H+ + 4 O2	Rattus norvegicus Sprague Dawley	overall reaction	2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P29476	-	-
Rattus norvegicus Sprague Dawley	P29476	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
dental papilla	dental papilla cells (DPCs) are mesenchymal cells that are surrounded by the enamel organ during tooth development	Rattus norvegicus	-
additional information	NO synthase (NOS) immunohistochemic analysis and nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH-d) staining in vivo in rat odontoblasts. The expression of neuronal NOS and endothelial NOS is upregulated during the odontoblastic differentiation of DPCs	Rattus norvegicus	-
odontoblast	from rats at different ages. Odontoblasts are strongly stained for NADPH-d. The staining intensity of odontoblasts near the future cusp and root is higher than that of other locations of the first molar. Odontoblasts in the first molar from 3-month-old rats are also positive for NADPH-d staining. Odontoblasts in the first molar from 8-month-old rats are weakly positive for NADPH-d staining. Semiquantitative evaluation results of NADPH-d staining suggests that NOS may be involved in the differentiation and function of odontoblasts	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2 L-arginine + 3 NADPH + 3 H+ + 4 O2	overall reaction	Rattus norvegicus	2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O	-	?
2 L-arginine + 3 NADPH + 3 H+ + 4 O2	overall reaction	Rattus norvegicus Sprague Dawley	2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O	-	?

Synonyms

Synonyms	Comment	Organism
NADPH-d	-	Rattus norvegicus
nicotinamide adenine dinucleotide phosphate-diaphorase	-	Rattus norvegicus
NO synthase	-	Rattus norvegicus
NOS	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Rattus norvegicus

Expression

Organism	Comment	Expression
Rattus norvegicus	expression of neuronal NOS and endothelial NOS is upregulated during the odontoblastic differentiation of dental papilla cells (DPCs)	up

General Information

General Information	Comment	Organism
malfunction	inhibition of NOS function by NOS inhibitor L-NG-monomethyl arginine (L-NMMA) results in reduced formation of mineralized nodules and expression of dentin sialophosphoprotein (DSPP) and dentin matrix protein (DMP1) during dental papilla cell (DPC) differentiation	Rattus norvegicus
physiological function	nitric oxide (NO) regulates the functions of multiple cells and organ tissues, including stem cell differentiation and bone formation, role of nitric oxide in odontoblastic differentiation of rat dental papilla cells, overview. NO regulates the odontoblastic differentiation of dental papilla cells (DPCs), thereby influencing dentin formation and tooth development. The NO donor S-nitroso-N-acetylpenicillamine (SNAP) promotes the viability of DPCs. Extracellular matrix mineralization and odontogenic markers expression are elevated by SNAP at low concentrations and suppressed at high concentration. Blocking the generation of cyclic guanosine monophosphate (cGMP) with 1H-(1,2,4)oxadiazolo-(4,3-a)quinoxalin-1-one (ODQ) abolishes the positive influence of SNAP on the odontoblastic differentiation of DPCs	Rattus norvegicus

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Release 2023.1 (January 2023)