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Literature summary for 1.14.13.39 extracted from

  • Dai, Y.; Haque, M.M.; Stuehr, D.J.
    Restricting the conformational freedom of the neuronal nitric-oxide synthase flavoprotein domain reveals impact on electron transfer and catalysis (2017), J. Biol. Chem., 292, 6753-6764 .
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginine + 3 NADPH + 3 H+ + 4 O2 Rattus norvegicus synthesis of the signaling molecule nitric oxide 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus P29476
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-

Purification (Commentary)

Purification (Comment) Organism
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Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
neuron
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Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine + 3 NADPH + 3 H+ + 4 O2
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Rattus norvegicus 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
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?
L-arginine + 3 NADPH + 3 H+ + 4 O2 synthesis of the signaling molecule nitric oxide Rattus norvegicus 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O
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?

Cofactor

Cofactor Comment Organism Structure
FAD during catalysis, NADPH-derived electrons are transfered into FAD and then distributed into the FMN domain for further transfer to internal or external heme groups. Conformational freedom of the FMN domain is essential for the electron transfer Rattus norvegicus
FMN during catalysis, NADPH-derived electrons are transfer into FAD and then distributed into the FMN domain for further transfer to internal or external heme groups. Conformational freedom of the FMN domain is essential for the electron transfer Rattus norvegicus

General Information

General Information Comment Organism
metabolism synthesis of the signaling molecule nitric oxide Rattus norvegicus