Activating Compound | Comment | Organism | Structure |
---|---|---|---|
tetrahydrobiopterin | - |
Staphylococcus aureus | |
tetrahydrobiopterin | - |
Bacillus subtilis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics and kinetic modelling, stopped-flow measurements | Staphylococcus aureus | |
additional information | - |
additional information | kinetics and kinetic modelling, stopped-flow measurements | Bacillus subtilis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | a heme enzyme, frequencies of electron transfer, overview | Staphylococcus aureus | |
Fe2+ | a heme enzyme, frequencies of electron transfer, overview | Bacillus subtilis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 | Staphylococcus aureus | - |
2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O | - |
? | |
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 | Bacillus subtilis | - |
2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bacillus subtilis | - |
- |
- |
Staphylococcus aureus | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O | reaction and kinetic mechanism | Staphylococcus aureus | |
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 = 2 L-citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O | reaction and kinetic mechanism | Bacillus subtilis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2 L-arginine + 2 NADPH + 2 H+ + 2 O2 | first half reaction via intermediate Nomega-hydroxy-L-arginine | Staphylococcus aureus | 2 Nomega-hydroxy-L-arginine + 2 NADP+ + 2 H2O | - |
? | |
2 L-arginine + 2 NADPH + 2 H+ + 2 O2 | first half reaction via intermediate Nomega-hydroxy-L-arginine | Bacillus subtilis | 2 Nomega-hydroxy-L-arginine + 2 NADP+ + 2 H2O | - |
? | |
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 | - |
Staphylococcus aureus | 2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O | - |
? | |
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 | - |
Bacillus subtilis | 2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O | - |
? | |
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 | overall reaction, two-step oxidation of L-arginine using an O2-dependent mechanism, detailed overview | Staphylococcus aureus | 2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O | - |
? | |
2 L-arginine + 3 NADPH + 3 H+ + 4 O2 | overall reaction, two-step oxidation of L-arginine using an O2-dependent mechanism, detailed overview | Bacillus subtilis | 2 citrulline + 2 nitric oxide + 3 NADP+ + 4 H2O | - |
? | |
additional information | mechanisms of oxygen activation by NOSs, overview | Staphylococcus aureus | ? | - |
? | |
additional information | mechanisms of oxygen activation by NOSs, overview | Bacillus subtilis | ? | - |
? | |
Nomega-hydroxy-L-arginine + NADPH + H+ + O2 | second half reaction via intermediate Nomega-hydroxy-L-arginine | Staphylococcus aureus | citrulline + nitric oxide + NADP+ + H2O | - |
? | |
Nomega-hydroxy-L-arginine + NADPH + H+ + O2 | second half reaction via intermediate Nomega-hydroxy-L-arginine | Bacillus subtilis | citrulline + nitric oxide + NADP+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NOS | - |
Staphylococcus aureus |
NOS | - |
Bacillus subtilis |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Staphylococcus aureus |
25 | - |
assay at | Bacillus subtilis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.6 | - |
assay at | Staphylococcus aureus |
7.6 | - |
assay at | Bacillus subtilis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
heme | frequencies of electron transfer, overview | Staphylococcus aureus | |
heme | frequencies of electron transfer, overview | Bacillus subtilis | |
NADPH | - |
Staphylococcus aureus | |
NADPH | - |
Bacillus subtilis |