Literature summary for 1.14.13.39 extracted from

Lacza, Z.; Puskar, M.; Figueroa, J.P.; Zhang, J.; Rajapakse, N.; Busija, D.W.
Mitochondrial nitric oxide synthase is constitutively active and is functionally upregulated in hypoxia (2001), Free Radic. Biol. Med., 31, 1609-1615.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Calmidazolium	calmodulin antagonist; complete inhibition	Mus musculus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Mus musculus	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2 L-arginine + 3 NADPH + 4 O2 + 3 H+	Mus musculus	-	2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O	-	?
2 L-arginine + 3 NADPH + 4 O2 + 3 H+	Mus musculus C57BL/6	-	2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-
Mus musculus C57BL/6	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Mus musculus	-
liver	-	Mus musculus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.000009	-	liver mitochondria	Mus musculus
0.000017	-	liver	Mus musculus
0.000033	-	brain mitochondria	Mus musculus
0.00054	-	brain	Mus musculus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2 L-arginine + 3 NADPH + 4 O2 + 3 H+	-	Mus musculus	2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O	-	?
2 L-arginine + 3 NADPH + 4 O2 + 3 H+	-	Mus musculus C57BL/6	2 L-citrulline + 2 NO + 3 NADP+ + 4 H2O	-	?

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
32	-	assay at	Mus musculus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.4	-	assay at	Mus musculus

Cofactor

Cofactor	Comment	Organism	Structure
5,6,7,8-tetrahydro-L-biopterin	-	Mus musculus
FAD	-	Mus musculus
FMN	-	Mus musculus
NADPH	-	Mus musculus

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Release 2023.1 (January 2023)