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Literature summary for 1.14.13.29 extracted from

  • Kallubai, M.; Amineni, U.; Mallavarapu, M.; Kadiyala, V.
    In silico approach to support that p-nitrophenol monooxygenase from Arthrobacter sp. strain JS443 catalyzes the initial two sequential monooxygenations (2015), Interdiscip. Sci. Comput. Life Sci., 7, 157-167 .
    View publication on PubMed
Search for more literature for 1.14.13.29

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4-nitrophenol + NAD(P)H + H+ + O2 Lysinibacillus sphaericus
-
 4-nitrocatechol + NAD(P)+ + H2O
-
 ?
4-nitrophenol + NAD(P)H + H+ + O2 Lysinibacillus sphaericus JS905
-
 4-nitrocatechol + NAD(P)+ + H2O
-
 ?
4-nitrophenol + NADH + H+ + O2 Arthrobacter sp.
-
 4-nitrocatechol + NAD+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Arthrobacter sp. A7YVV2
-
-
Lysinibacillus sphaericus
-
-
-
Lysinibacillus sphaericus JS905
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenol + NAD(P)H + H+ + O2
-
 Lysinibacillus sphaericus 4-nitrocatechol + NAD(P)+ + H2O
-
 ?
4-nitrophenol + NAD(P)H + H+ + O2
-
 Lysinibacillus sphaericus JS905 4-nitrocatechol + NAD(P)+ + H2O
-
 ?
4-nitrophenol + NADH + H+ + O2
-
 Arthrobacter sp. 4-nitrocatechol + NAD+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
4-nitrophenol 4-monooxygenase/4-nitrocatechol 2-monooxygenase UniProt Lysinibacillus sphaericus
4-nitrophenol 4-monooxygenase/4-nitrocatechol 2-monooxygenase UniProt Arthrobacter sp.
PNP monooxygenase
-
 Lysinibacillus sphaericus
PNP monooxygenase
-
 Arthrobacter sp.
two-component PNP monooxygenase
-
 Lysinibacillus sphaericus
two-component PNP monooxygenase
-
 Arthrobacter sp.

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Lysinibacillus sphaericus
FAD
-
 Arthrobacter sp.
NADH
-
 Lysinibacillus sphaericus
NADH
-
 Arthrobacter sp.

General Information

General Information Comment Organism
evolution PNP monooxygenase belongs to a two-component flavin-diffusible monooxygenase family Lysinibacillus sphaericus
metabolism the enzyme PNP monoxygenase is involved in the degradation of 4-nitrophenol, proposed pathway, overview. 4-Nitrophenol is converted to 4-nitrocatechol by a 4-nitrophenol 2-monooxygenase, EC 1.14.13.29, of the enzyme, which is subsequently converted to 2-hydroxy-1,4-benzoquinone, EC 1.14.13.166 Lysinibacillus sphaericus
metabolism the enzyme PNP monoxygenase is involved in the degradation of 4-nitrophenol, proposed pathway, overview. 4-Nitrophenol is converted to 4-nitrocatechol by a 4-nitrophenol 2-monooxygenase, EC 1.14.13.29, of the enzyme, which is subsequently converted to 2-hydroxy-1,4-benzoquinone, EC 1.14.13.166 Arthrobacter sp.
additional information enzyme structure homology model for PNP monooxygenase using crystal structure of chlorophenol 4-monooxygenase from Burkholderia cepacia AC1100, PDB IS 3HWC, as template. Molecular dynamics simulations performed for docking complexes show the stable interaction between enzyme and substrate 4-nitrocatechol of substrates into the active site of PNP monooxygenase, overview Arthrobacter sp.
additional information enzyme structure homology model for PNP monooxygenase using crystal structure of chlorophenol 4-monooxygenase from Burkholderia cepacia AC1100, PDB IS 3HWC, as template. Molecular dynamics simulations performed for docking complexes show the stable interaction between enzyme and substrate 4-nitrocatechol. Docking of substrates into the active site of PNP monooxygenase, Arg100, Gln158 and Thr193 are the key catalytic residues, overview Lysinibacillus sphaericus
physiological function the enzyme comprises two components, a flavoprotein reductase and an oxygenase, catalyzes the initial two sequential monooxygenations to convert 4-nitrophenol to trihydroxybenzene, EC 1.14.13.29 and EC 1.14.13.166 Arthrobacter sp.
physiological function the enzyme comprises two components, a flavoprotein reductase and an oxygenase, catalyzes the initial two sequential monooxygenations to convert PNP to trihydroxybenzene, EC 1.14.13.29 and EC 1.14.13.166 Lysinibacillus sphaericus