Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.13.29 extracted from

  • Carvalho, R.S.; Friedrich, K.; De-Oliveira, A.C.; Suarez-Kurtz, G.; Paumgartten, F.J.
    Malaria downmodulates mRNA expression and catalytic activities of CYP1A2, 2E1 and 3A11 in mouse liver (2009), Eur. J. Pharmacol., 616, 265-269.
    View publication on PubMed
Search for more literature for 1.14.13.29

Application

Application Comment Organism
medicine malaria decreases the activity of p-nitrophenol-hydroxylase in liver microsomes by 33%, mRNA levels are lowered compared to uninfected mice Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Mus musculus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
p-nitrophenol + NADH + H+ + O2 Mus musculus
-
 p-nitrocatechol + NAD+ + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 male Swiss Webster mice infected by malaria pathogen Plasmodium berghei ANKA
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.00275
-
 malaria infected mouse, real time kinetic method Mus musculus
0.00411
-
 mouse without infection, real time kinetic method Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
p-nitrophenol + NADH + H+ + O2
-
 Mus musculus p-nitrocatechol + NAD+ + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CYP2E1
-
 Mus musculus
p-nitrophenol-hydroxylase
-
 Mus musculus
PNPH
-
 Mus musculus