Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe | Fe(IV) diiron complexes | Methylosinus trichosporium |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
methane + NAD(P)H + H+ + O2 | Methylosinus trichosporium | - |
methanol + NAD(P)+ + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Methylosinus trichosporium | A0A2D2D5X0 AND A0A2D2D0T8 AND Q53563 AND A0A2D2D0X7 | MMOH, MMOR, MMOB, and MMOD | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
methane + NAD(P)H + H+ + O2 = methanol + NAD(P)+ + H2O | reaction mechanism with transition states, MMOHred to MMOHox transitions for open cores of MMOHQ, detailed overview. The reactivity of the Fe(IV)=O unit is modulated by the ligand to the second iron | Methylosinus trichosporium |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
methane + NAD(P)H + H+ + O2 | - |
Methylosinus trichosporium | methanol + NAD(P)+ + H2O | - |
? |
Synonyms | Comment | Organism |
---|---|---|
sMMO | - |
Methylosinus trichosporium |
soluble methane monooxygenase | - |
Methylosinus trichosporium |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Methylosinus trichosporium | |
NADH | - |
Methylosinus trichosporium | |
NADPH | - |
Methylosinus trichosporium |
General Information | Comment | Organism |
---|---|---|
additional information | structure-spectroscopy correlations for intermediate Q of soluble methane monooxygenase, QM/MM calculations. Modeling of the MMOH oxidative and reductive state, Moessbauer parameters and electronic structure of MMOHox. The selection of plausible models include the following: (1) bis-mu-oxo bridged cores, (2) mu-OepsilonGlu243 bridged diamond cores, inspired from the MMOHred structure, as suggested recently, (3) mu-oxo bridged open cores, and (4) mu-OepsilonGlu243 bridged open cores. Closed- and open-core conformations for the key intermediate in sMMO. Optimized cores of eight MOHQ models are analyzed for molecular structure and electronic structure | Methylosinus trichosporium |