Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[F-actin]-L-methionine + NADPH + O2 + H+ | Drosophila melanogaster | - |
[F-actin]-L-methionine-(R)-S-oxide + NADP+ + H2O | Mical post-translationally oxidizes the methionine 44 residue within the D-loop of actin, simultaneously severing filaments and decreasing polymerization | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | Q86BA1 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[F-actin]-L-methionine + NADPH + O2 + H+ | - |
Drosophila melanogaster | [F-actin]-L-methionine-(R)-S-oxide + NADP+ + H2O | Mical post-translationally oxidizes the methionine 44 residue within the D-loop of actin, simultaneously severing filaments and decreasing polymerization | ? |
General Information | Comment | Organism |
---|---|---|
physiological function | F-actin is a direct and specific substrate for Mical. The reaction alters actin at a specific amino acid residue disrupting actin-actin associations and fragmenting filaments. The modified actin no longer polymerizes normally. Mical modifies the pointed-end of actin proteins, and not the fast-growing, membrane-proximal barbed-end. Therefore actin reassembly and branching follows Semaphorin/Plexin/Mical-mediated F-actin collapse | Drosophila melanogaster |