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Literature summary for 1.14.13.225 extracted from

  • Hung, R.J.; Pak, C.W.; Terman, J.R.
    Direct redox regulation of F-actin assembly and disassembly by Mical (2011), Science, 334, 1710-1713.
    View publication on PubMedView publication on EuropePMC

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
[F-actin]-L-methionine + NADPH + O2 + H+ Drosophila melanogaster
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[F-actin]-L-methionine-(R)-S-oxide + NADP+ + H2O Mical post-translationally oxidizes the methionine 44 residue within the D-loop of actin, simultaneously severing filaments and decreasing polymerization ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster Q86BA1
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
[F-actin]-L-methionine + NADPH + O2 + H+
-
Drosophila melanogaster [F-actin]-L-methionine-(R)-S-oxide + NADP+ + H2O Mical post-translationally oxidizes the methionine 44 residue within the D-loop of actin, simultaneously severing filaments and decreasing polymerization ?

General Information

General Information Comment Organism
physiological function F-actin is a direct and specific substrate for Mical. The reaction alters actin at a specific amino acid residue disrupting actin-actin associations and fragmenting filaments. The modified actin no longer polymerizes normally. Mical modifies the pointed-end of actin proteins, and not the fast-growing, membrane-proximal barbed-end. Therefore actin reassembly and branching follows Semaphorin/Plexin/Mical-mediated F-actin collapse Drosophila melanogaster