Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.14.13.196 extracted from

  • Franceschini, S.; Fedkenheuer, M.; Vogelaar, N.J.; Robinson, H.H.; Sobrado, P.; Mattevi, A..
    Structural insight into the mechanism of oxygen activation and substrate selectivity of flavin-dependent N-hydroxylating monooxygenases (2012), Biochemistry, 51, 7043-7045.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
crystal structure of the enzyme bound to NADP+ and L-ornithine (1.9 A resolution), crystal structure of the enzyme bound to NADP+ and L-lysine (2.28 A resolution), crystal structure of the enzyme (reduced state) bound to NADPH (2.32 A resolution), crystal structure of the enzyme (reduced state) bound to NADP+ and L-arginine (2.9 A resolution), crystal structure of the enzyme (re-oxidized state) bound to NADP+ and L-ornithine (2.75 A resolution), crystal structure of the enzyme (re-oxidized state) bound to NADP+ and L-arginine (2.29 A resolution), crystal structure of the enzyme bound to L-ornithine (2.3 A resolution) Aspergillus fumigatus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-ornithine + NADH + H+ + O2 Aspergillus fumigatus the enzyme catalyzes the generation of N5-hydroxyornithine in the biosynthesis of siderophores, a reaction essential for virulence N5-hydroxy-L-ornithine + NAD+ + H2O
-
?
L-ornithine + NADPH + H+ + O2 Aspergillus fumigatus the enzyme catalyzes the generation of N5-hydroxyornithine in the biosynthesis of siderophores, a reaction essential for virulence N5-hydroxy-L-ornithine + NADP+ + H2O
-
?

Organism

Organism UniProt Comment Textmining
Aspergillus fumigatus Q5SE95
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-ornithine + NADH + H+ + O2 the enzyme catalyzes the generation of N5-hydroxyornithine in the biosynthesis of siderophores, a reaction essential for virulence Aspergillus fumigatus N5-hydroxy-L-ornithine + NAD+ + H2O
-
?
L-ornithine + NADPH + H+ + O2 the enzyme catalyzes the generation of N5-hydroxyornithine in the biosynthesis of siderophores, a reaction essential for virulence Aspergillus fumigatus N5-hydroxy-L-ornithine + NADP+ + H2O
-
?

Synonyms

Synonyms Comment Organism
SidA
-
Aspergillus fumigatus