Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q80Y84 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
JARID1B | - |
Mus musculus |
KDM5B | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
physiological function | knockout or inhibition of Jarid1b prevents the development of endothelial dysfunction in response to angiotensin AngII, accompanied by a loss of the inflammatory response to AngII. AngII induces the soluble epoxide hydrolase (sEH). Knockout or inhibition of Jarid1b prevents the AngII-mediated sEH induction. Jarid1b maintains the length of the 3'-untranslated region of the sEH mRNA, thereby increasing its stability and thus sEH protein expression | Mus musculus |