Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Rattus norvegicus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 | Rattus norvegicus | - |
histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2 | - |
? | |
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 | Rattus norvegicus Sprague-Dawley | - |
histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2 | - |
? | |
histone H3 N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2 | Rattus norvegicus | - |
histone H3 N6-methyl-L-lysine4 + succinate + formaldehyde + CO2 | - |
? | |
histone H3 N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2 | Rattus norvegicus Sprague-Dawley | - |
histone H3 N6-methyl-L-lysine4 + succinate + formaldehyde + CO2 | - |
? | |
histone H3 N6-methyl-L-lysine4 + 2-oxoglutarate + O2 | Rattus norvegicus | - |
histone H3 L-lysine4 + succinate + formaldehyde + CO2 | - |
? | |
histone H3 N6-methyl-L-lysine4 + 2-oxoglutarate + O2 | Rattus norvegicus Sprague-Dawley | - |
histone H3 L-lysine4 + succinate + formaldehyde + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Rattus norvegicus Sprague-Dawley | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amygdala | - |
Rattus norvegicus | - |
brain | the distributions of H3-K4 mono-, di-, and tri-methylated histones exhibit exactly the same pattern as the LSD1 protein, immunofluoresecence histochemic analysis, overview | Rattus norvegicus | - |
cerebral cortex | - |
Rattus norvegicus | - |
corpus striatum | - |
Rattus norvegicus | - |
hippocampus | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 | - |
Rattus norvegicus | histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2 | - |
? | |
histone H3 N6,N6,N6-trimethyl-L-lysine4 + 2-oxoglutarate + O2 | - |
Rattus norvegicus Sprague-Dawley | histone H3 N6,N6-dimethyl-L-lysine4 + succinate + formaldehyde + CO2 | - |
? | |
histone H3 N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2 | - |
Rattus norvegicus | histone H3 N6-methyl-L-lysine4 + succinate + formaldehyde + CO2 | - |
? | |
histone H3 N6,N6-dimethyl-L-lysine4 + 2-oxoglutarate + O2 | - |
Rattus norvegicus Sprague-Dawley | histone H3 N6-methyl-L-lysine4 + succinate + formaldehyde + CO2 | - |
? | |
histone H3 N6-methyl-L-lysine4 + 2-oxoglutarate + O2 | - |
Rattus norvegicus | histone H3 L-lysine4 + succinate + formaldehyde + CO2 | - |
? | |
histone H3 N6-methyl-L-lysine4 + 2-oxoglutarate + O2 | - |
Rattus norvegicus Sprague-Dawley | histone H3 L-lysine4 + succinate + formaldehyde + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
LSD1 | - |
Rattus norvegicus |
lysine-specific demethylase 1 | - |
Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | LSD1 expression in the brain is induced both region and cell specifically after ischemic/perfusion | up |
General Information | Comment | Organism |
---|---|---|
physiological function | The lysine-specific histone demethylase 1 is a chromatin modifying enzyme that specifically removes methyl groups from lysine 4 of histone 3 and induces transcriptional repression. Tightly regulated distribution for LSD1 in the brain of rats under ischemic insult, suggesting a critical role in neuron function, overview | Rattus norvegicus |