Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
General Information | Comment | Organism |
---|---|---|
physiological function | JMJD1A is regulated by hypoxia-inducible factor HIF-2alpha in HepG2 cells under hypoxia. Knockdown or overexpression of JMJD1A can decrease or increase erythropoietin expression, respectively. JMJD1 A can interact with HIF-2alpha to form a coactivator complex, which binds to the hypoxia response elements of erythropoietin and increases erythropoietin expression by catalyzing demethylation of H3K9me2, a transcription suppression marker | Homo sapiens |