Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Mus musculus | 5634 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q6PCM1 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryonic stem cell | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
JMJD1A | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Mus musculus | expression is positively regulated by the embryonic stem cell transcription factor Oct4 | up |
General Information | Comment | Organism |
---|---|---|
physiological function | Jmjd1a depletion leads to embryonic stem cell differentiation, which is accompanied by a reduction in the expression of embryonic stem cell-specific genes and an induction of lineage marker genes. Jmjd1a demethylates H3K9Me2 at the promoter regions of Tcl1, Tcfcp2l1, and Zfp57 and positively regulates the expression of these pluripotency-associated genes | Mus musculus |