Cloned (Comment) | Organism |
---|---|
quantitative RT-PCR enzyme expression analysis | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | knockdown of JMJD1C in esophageal cancer cell lines, generation of Eca-109 and EC-18 EC cells that stably express JMJD1C shRNA | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nucleus | - |
Homo sapiens | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 | Homo sapiens | - |
histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q15652 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
EC-18 cell | - |
Homo sapiens | - |
Eca109 cell | - |
Homo sapiens | - |
esophageal epithelial cell | - |
Homo sapiens | - |
esophageal epithelium | enzyme JMJD1C is upregulated in patient esophageal cancer tissues and different esophageal cancer cell lines | Homo sapiens | - |
esophageal epithelial cell | - |
Homo sapiens | - |
HKESC-1 cell | - |
Homo sapiens | - |
KYSE-140 cell | - |
Homo sapiens | - |
KYSE-30 cell | - |
Homo sapiens | - |
NEEC-3 cell | - |
Homo sapiens | - |
normal esophageal epithelial cell | - |
Homo sapiens | - |
primary culture | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
histone H3 N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 | - |
Homo sapiens | histone H3 N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
histone demethylase JMJD1C | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | knockdown of JMJD1C inhibits esophageal cancer cell proliferation. Knockdown of JMJD1C represses the protein and mRNA levels of YAP1 via regulating the H3K9me2 activity, but not the H3K9me1 activity. Inhibition of EC cell proliferation by the knockdown of JMJD1C is rescued by overexpression of YAP1, YAP1 acts as an oncogene in tumor progression | Homo sapiens |
physiological function | histone demethylase JMJD1C regulates esophageal cancer proliferation via YAP1 signaling. JMJD1C controls the proliferation of esophageal cancer via modulation of H3K9me2 activity, targeting the YAP1 gene expression and functions as a tumor suppressor in esophageal cancer. JMJD1C levels are positively correlated with the TNM stage | Homo sapiens |