Literature summary for 1.14.11.65 extracted from

Wellmann, S.; Bettkober, M.; Zelmer, A.; Seeger, K.; Faigle, M.; Eltzschig, H.K.; Buehrer, C.
Hypoxia upregulates the histone demethylase JMJD1A via HIF-1 (2008), Biochem. Biophys. Res. Commun., 372, 892-897.

Search for more literature for 1.14.11.65

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y4C1	hypoxia can stimulate enzyme mRNA and protein expression, involving binding of hypoxia-induced factor 1 to a specific hypoxia responsive element in the enzyme's promoter	-
Rattus norvegicus	Q63679	hypoxia can stimulate enzyme mRNA and protein expression involving binding of hypoxia-induced factor 1 to a specific hypoxia responsive element in the enzyme's promoter	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	high basal expression with 2.3-fold increase in mRNA after 6 h of hypoxia	Rattus norvegicus	-
heart	3.3fold increase in mRNA after 6 h of hypoxia	Rattus norvegicus	-
HEK-293 cell	up-regulation of mRNA and protein after exposure to hypoxia or iron scavengers in vitro. Blocking of hypoxia-inducible factor 1 signaling abrogates the up-regulation	Homo sapiens	-
kidney	1.8fold increase in mRNA after 6 h of hypoxia	Rattus norvegicus	-
liver	7.7fold increase in mRNA after 6 h of hypoxia	Rattus norvegicus	-
additional information	mRNA expression is increased in most tissues of human fetuses in whom oxygen supply is low compared to postnatal levels	Homo sapiens	-

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Release 2023.1 (January 2023)