Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-acetyluracil | poor competitive inhibitor | Rhodotorula glutinis | |
5-Formyluracil | competitive inhibitor with respect to thymine | Rhodotorula glutinis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0011 | - |
Fe2+ | - |
Rhodotorula glutinis | |
0.024 | - |
2-oxoglutarate | - |
Rhodotorula glutinis | |
0.036 | - |
O2 | - |
Rhodotorula glutinis | |
0.058 | - |
thymine | - |
Rhodotorula glutinis | |
0.087 | - |
5,6-dihydroxythymine | - |
Rhodotorula glutinis | |
0.118 | - |
5-Hydroxymethyluracil | - |
Rhodotorula glutinis | |
0.124 | - |
5-(2-hydroxyethyl)uracil | - |
Rhodotorula glutinis | |
0.322 | - |
5-fluorouracil | - |
Rhodotorula glutinis | |
1.3 | - |
1-methylthymine | - |
Rhodotorula glutinis | |
2.34 | - |
5-Formyluracil | - |
Rhodotorula glutinis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Fe2+ | non-heme | Rhodotorula glutinis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-formyluracil + 2-oxoglutarate + O2 | Rhodotorula glutinis | - |
5-carboxyuracil + succinate + CO2 | - |
? | |
5-hydroxymethyluracil + 2-oxoglutarate + O2 | Rhodotorula glutinis | - |
5-formyluracil + succinate + CO2 | 5-formyluracil reacts subsequently to 5-carboxyuracil | ? | |
thymine + 2-oxoglutarate + O2 | Rhodotorula glutinis | stereospecific removal of the pro-S hydrogen | 5-hydroxymethyluracil + succinate + CO2 | 5-hydroxymethyluracil reacts subsequently to 5-formyluracil | ? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rhodotorula glutinis | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Rhodotorula glutinis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-methylthymine + 2-oxoglutarate + O2 | - |
Rhodotorula glutinis | 1-methyl-5-(hydroxymethyl)uracil + thymine + formaldehyde + succinate + CO2 | - |
? | |
5,6-dihydrothymine + 2-oxoglutarate + O2 | - |
Rhodotorula glutinis | 5,6-dihydro-5-(hydroxymethyl)uracil + succinate + CO2 | - |
? | |
5,6-dihydroxythymine + 2-oxoglutarate + O2 | - |
Rhodotorula glutinis | 5,6-dihydro-5-(hydroxymethyl)uracil + succinate + CO2 | - |
r | |
5-(2-hydroxyethyl)uracil + 2-oxoglutarate + O2 | - |
Rhodotorula glutinis | 5-(1,2-dihydroxyethyl)uracil + succinate + CO2 | - |
? | |
5-(methylthio)uracil + 2-oxoglutarate + O2 | - |
Rhodotorula glutinis | 5-(methylsulfonyl)uracil + 5-(methylsulfinyl)uracil + succinate + CO2 | - |
? | |
5-fluorouracil + 2-oxoglutarate + O2 | - |
Rhodotorula glutinis | ? + succinate + CO2 | - |
? | |
5-formyluracil + 2-oxoglutarate + O2 | - |
Rhodotorula glutinis | 5-carboxyuracil + succinate + CO2 | - |
? | |
5-formyluracil + 2-oxoglutarate + O2 | 5-formyluracil reacts subsequently to 5-carboxyuracil | Rhodotorula glutinis | 5-carboxyuracil + succinate + CO2 | - |
? | |
5-hydroxymethyluracil + 2-oxoglutarate + O2 | - |
Rhodotorula glutinis | 5-formyluracil + succinate + CO2 | - |
? | |
5-hydroxymethyluracil + 2-oxoglutarate + O2 | - |
Rhodotorula glutinis | 5-formyluracil + succinate + CO2 | 5-formyluracil reacts subsequently to 5-carboxyuracil | ? | |
5-vinyluracil + 2-oxoglutarate + O2 | - |
Rhodotorula glutinis | 5-(1,2-dihydroxyethyl)uracil + succinate + CO2 | - |
? | |
thymine + 2-oxoglutarate + O2 | stereospecific removal of the pro-S hydrogen | Rhodotorula glutinis | 5-hydroxymethyluracil + succinate + CO2 | 5-hydroxymethyluracil reacts subsequently to 5-formyluracil | ? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.83 | - |
5-acetyluracil | - |
Rhodotorula glutinis | |
1.39 | - |
5-Formyluracil | with respect to thymine | Rhodotorula glutinis |