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Literature summary for 1.14.11.4 extracted from

  • Murray, J.C.; Cassell, R.H.; Pinnell, S.R.
    Inhibition of lysyl hydroxylase by catechol analogs (1977), Biochim. Biophys. Acta, 481, 63-70.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Adrenochrome slight Gallus gallus
catechol
-
Gallus gallus
DL-Serine 2-[(2,3,4-trihydroxyphenyl)methyl]hydrazide most potent Gallus gallus
dopamine
-
Gallus gallus
ephedrine slight Gallus gallus
epinephrine
-
Gallus gallus
norepinephrine
-
Gallus gallus
phenylalanine slight Gallus gallus
Phenylephedrine slight Gallus gallus
pyrogallol most potent Gallus gallus
tyrosine slight Gallus gallus

Metals/Ions

Metals/Ions Comment Organism Structure
Fe2+
-
Gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
collagen + 2-oxoglutarate + O2 Gallus gallus influence the integrity and stability of collagen 5-hydroxylysyl-collagen + succinate + CO2
-
?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification hydroxylation of lysyl residue in -X-Lys-Gly Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
collagen + 2-oxoglutarate + O2 influence the integrity and stability of collagen Gallus gallus 5-hydroxylysyl-collagen + succinate + CO2
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.015
-
catechol
-
Gallus gallus